Nature Sub-Journal: Heat-controllable CAR-T cells can destroy tumors and prevent recurrence

CAR-T cell therapy involves modifying the patient's T cells (a type of white blood cell) in the laboratory

This is a new, evolving and vigorous field of immunotherapy.

Gabe Kwong, associate professor of the Wallace H.

Kwong and his collaborators are changing the environment and making some modifications to their own cells to enhance the way CAR-t cells fight cancer

This latest research is based on the laboratory's research on remotely controlled cell therapy.

In the early studies, the researchers did not perform clinical treatments for tumors, but they are now conducting new research

Kwong said that the real novelty lies in the genetic engineering of clinical grade CAR-T cells, which the team has been studying for the past three years

The localized production of these effective, engineered proteins (cytokines and bispecific t cell adaptors) must be precisely controlled

Kwong said: "These anti-cancer proteins are really good at stimulating CAR-T cells, but they are too toxic to be used outside tumors

The latest research shows that the system cures cancer in mice, and the team’s method not only shrinks tumors, but also prevents recurrence-which is essential for long-term survival

"We will use focused ultrasound, which is completely non-invasive and can target any part of the body," Kuang said

Journal Reference :

1. Ian C.