Nature Sub-Journal: In-depth analysis of alcohol addiction through multi-omics methods

Researchers from the Icahn School of Medicine at Mount Sinai in the United States recently published the first multi-omics study in the field of addiction genetics in the journal Nature Communications

They used multi-omics methods to discover a large number of candidate genes related to drinking and alcohol use disorders

Alcohol Use Disorder (AUD) is a mental disorder with complex etiology that covers some of the undesirable conditions that people call alcoholism, alcohol dependence and alcohol addiction

Previous GWAS studies have identified the loci associated with drinking, and this study aims to determine the mutations and the genes themselves

In order to identify genes related to AUD and drinking per week (DPW), the research team integrated multiple omics data

Using data from these organizations, they fine-tuned the complex loci and identified possible mutations and candidate genes, including the SPI1 and MAPT genes related to alcoholism

The SPI1 gene encodes the ETS domain transcription factor (PU.

The MAPT gene encodes the Tau protein

Senior author, Professor Alison Goate of Icahn School of Medicine, said: "This work may bring new approaches to the treatment of alcohol use disorders

Dr.

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Kapoor, M.