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    Home > Biochemistry News > Biotechnology News > Nature Sub-Journal: Looking for new channels to selectively target pests

    Nature Sub-Journal: Looking for new channels to selectively target pests

    • Last Update: 2021-12-28
    • Source: Internet
    • Author: User
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    Figure: Schematic diagram of Slo in the Ca2+ non-activated conformation (left) and Ca2+ combined activation conformation (right)


    The common slow poke potassium ion channels in Drosophila are huge and complex proteins located in the cell membrane.


    In order to design drugs against pests, scientists need high-resolution ion channel structures


    Detailed diagram of the drug discovery potassium channel

    A specific position in this channel is called the RCK2 pocket, and its amino acids differ between Drosophila and humans


    In addition, the researchers also solved the low-temperature em structure of the channel with two known compounds, verructin and emodepside


    Article title

    Small molecule modulation of the Drosophila Slo channel elucidated by cryo-EM


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