Nature Sub-Journal: Not only exosomes, cells also contain super particles

Researchers at Vanderbilt University Medical Center in the United States have recently discovered a type of nanoparticles released from cells

The results, published in the journal Nature Cell Biology, are expected to help people understand the role of extracellular vesicles and nanoparticles in the transmission of important chemical "information" between cells

Corresponding author, Professor Robert Coffey of Vanderbilt University Medical Center said: "We have identified multiple biomarkers and therapeutic targets for cancer and other disease states.

Professor Robert Coffey is a well-known intestinal oncologist and is internationally renowned for his research on colorectal cancer

In 2019, a researcher in the Coffey laboratory, Dr.

In the latest research, Dr.

Researchers report that supermere is morphologically different from exocrine particles.

On the one hand, supermere carries most of the extracellular RNA released by the cell, and these RNAs are present in the blood

Researchers have discovered that supermere is an important carrier of TGFBI.

They also carry ACE2, a cell surface receptor that plays a role in cardiovascular disease and the target of the new coronavirus SARS-CoV-2

Another potentially important cargo is APP, which is a beta amyloid precursor protein involved in the progression of Alzheimer's disease

In general, this study identified a unique functional nanoparticle, which is full of potential biomarkers and therapeutic targets for many human diseases

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Zhang, Q.