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    Home > Biochemistry News > Biotechnology News > Nature Sub-Journal: Single Cell Fine Lipidomics Technology

    Nature Sub-Journal: Single Cell Fine Lipidomics Technology

    • Last Update: 2021-08-11
    • Source: Internet
    • Author: User
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    On May 17, the mass spectrometry research team of the Department of Precision Instrumentation of Tsinghua University published a report on the single-cell lipid group fine structure characterization technology based on mass spectrometry, which realized large-scale fine structure analysis of lipids in mammalian single cells and solved the field of single-cell mass spectrometry.


    With the aging of the population and changes in life>


    Mass spectrometer has become the main technique for single-cell lipidome analysis due to its high sensitivity, high specificity and accurate quantitative ability


    The study uses this new technology to carry out single-cell fine lipidomics analysis on wild-type (HCC827) and drug-resistant (HCC827/GR6) non-small cell lung cancer (NSCLC) cells, and realizes a lipid-based C=C Differentiation of sensitive and drug-resistant lung cancer cells by isoform analysis


    Related work was recently published in Nature Communications under the title of "Single-cell lipidomics with high structural specificity by mass spectrometry"


    The first author of this article is Li Zishuai, a PhD student in the Department of Precision Instrument, and the corresponding authors are Associate Professor Ma Xiaoxiao and Professor Ouyang Zheng of the Department of Precision Instrument.


    Paper link:

    https://

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