[Nature Sub-Journal] The 3D pancreatic cancer tumor model cultivated by an international team of scientists including Shanghai Jiaotong University can effectively improve the treatment of pancreatic cancer

This article is original by Translational Medicine Network.
Please indicate the source for reprinting.
Author: Daisy Guide: Published in a new study in Nature Communications on September 24, University of Nottingham, Queen Mary University of London, Monash University and Shanghai Jiaotong University Co-created a multi-cell 3D pancreatic cancer tumor model, using patient-derived cells to reproduce the growth pattern of tumor cells in pancreatic cancer, and study tumor growth and progression
.

Traditional 2D cell cultures cannot simulate the key characteristics of tumor tissues, and tailor-made ex vivo models can truly review their performance in vivo, which may be particularly beneficial to the management of pancreatic ductal adenocarcinoma (PDAC)
.

This model provides a more relevant microenvironment than organoids and spherical cultures
.

Most importantly, compared with other models, the drug response was better reproduced in its self-assembly culture
.

An international team of scientists created a three-dimensional (3D) pancreatic cancer tumor model in the laboratory, which combines a bioengineered matrix and patient-derived cells, which can be used to develop and test targeted therapies
.

In a new study published in "Nature Communications" on September 24, researchers from the University of Nottingham, Queen Mary University of London, Monash University and Shanghai Jiaotong University created a multicellular three-dimensional microenvironment that uses patient sources The cells reproduce the growth pattern of tumor cells in pancreatic cancer and respond to chemotherapy drugs
.

The researchers published an article titled "Bioengineered 3D models of human pancreatic cancer recapitulate in vivo tumour biology"
.

DOI: 10.
1038/s41467-021-25921-9 Pancreatic cancer is known as the "King of Cancer" in the field of oncology.
It is difficult to treat, especially if there are no signs or symptoms before the cancer has spread
.

Compared with other cancers, it is resistant to treatment and has a lower survival rate
.
The survival rate after diagnosis is only 5-10% .

The research was led by Professor Alvaro Mata from the University of Nottingham, United Kingdom, Daniela Loessner from Monash University, Australia, and Christopher Heeschen from Shanghai Jiaotong University, China
.

Dr.
David Osuna de la Peña is the lead researcher of the project.
He said: “There are two main obstacles to the treatment of pancreatic cancer.
The existence of sexual cancer stem cells (CSCs)
.

"In recent years, the theory of cancer stem cells (CSCs) has received great attention and recognition
.

CSCs are a type of cancer cells that exist in tumor tissues that are similar to stem cells with characteristics such as immortal proliferation, self-renewal, and multidirectional differentiation.
They are often the culprits of malignant tumor growth, proliferation, drug resistance, and metastasis.
Targeting CSCs has the hope of conquering cancer
.

"In our research, we designed a matrix in which CSCs can interact with other types of cells, and together behave more like their behavior in the body.
Treatment methods offer possibilities
.

"Next, it is necessary to improve the 3D cancer model to study the tumor growth and progression of patients, and to study the response to new therapies
.

Currently, 90% of successful cancer treatments in preclinical trials have failed in the early stages of clinical trials, with less than 5 % Of tumor drugs are successful in clinical trials
.

Preclinical trials mainly rely on laboratory-grown two-dimensional (2D) cell cultures and animal models to predict treatment response
.

However, traditional two-dimensional cell cultures cannot simulate the key characteristics of tumor tissue differences between species can cause many successful treatment of an animal host body but ineffective in humans
.

Therefore, new experimental cancer models to better three-dimensional reconstruction of human tumor microenvironment, in conjunction with the patient-specific differences
.

since Assembly is a process by which a biological system can controllably assemble multiple molecules and cells into functional tissues
.

Using this process, the team created a new hydrogel biomaterial, which is composed of multiple but specific types found in pancreatic cancer.
made of protein
.

this formation mechanism of the key cell types can integrate, thereby creating a tumor characteristics of the patients can simulate biological environment
.

Professor Mata added: "in the development of methods of treating diseases using human cancer model becomes It is becoming more and more common, but one of the main obstacles to putting them into clinical application is turnaround time
.

By assembling with patient-derived cells and organizing key matrix components, we designed a more comprehensive and adjustable pancreatic ductal adenocarcinoma based on the 3D joint assembly of peptide amphibians (PA) and custom ECM components (PA-ECM) (PDAC) model
.

These cultures maintain patient-specific transcriptional characteristics and exhibit CSC functions, including strong tumorigenicity in vivo
.

Overall, it provides more relevant scenarios than organoids and spherical cultures
.

Most importantly, the drug response is better reproduced in our self-assembly culture than other models
.

"The design and characteristics of the PA-ECM joint assembly matrix.
Researchers believe that this model can be realized in a short period of time-extract the patient’s tumor cells in the hospital and incorporate them into the model to find the best treatment plan for a specific cancer.
And return it to the patient's vision
.

Although this vision of precision medicine for treating this disease is still a long way away, this research has taken an important step toward realizing this vision
.

References: 1.
https:// medicalxpress.
com/news/2021-09-lab-grown-tumor-treatment-pancreatic.
html2.
https:// Note: This article aims to introduce medical research progress , Cannot be used as a reference for the treatment plan
.

If you need health guidance, please go to a regular hospital for treatment
.

Popular·Article Gene Sequencing [Hot Discussion] How to achieve more uniform and accurate genetic testing? Shock! Two top genetic testing companies performed liquid biopsies on the same group of cancer patients, and the results were quite different.
The new coronavirus [Nature Hot Discussion] The new coronavirus is getting more and more powerful, but the protective efficacy of the vaccine is gradually weakening.
What should we do? New Coronavirus [Nature Hot Discussion] The epidemic in Fujian has spread to four places! Israel’s 1.
1 million large-scale study: The vaccinated booster shot is 19.
5 times less likely to be infected with the new crown than people who have only received two injections.
[Science] Nearly 500 million people live in areas where the coronavirus may overflow.
The new crown is just the tip of the iceberg.
There will be more SARS-like viruses! Gut Microorganism [Genome Medicine] is the first to use gut microbial data for the prognosis study of rheumatoid arthritis, which is expected to become the key to future treatment! Organoid Research [Nature Sub-Journal] The use of synthetic new gels can easily cultivate pancreatic "organoids" and accurately replicate human pancreatic tumor research [The Lancet] Low-dose CT screening for lung cancer can really effectively reduce mortality NS? British scientists will show you the answer through experiments! New crown virus [heavy weight] How protective is the new crown vaccine against delta virus? The US Centers for Disease Control and Prevention has given the answer: The death rate of the unvaccinated population is 11 times that of the vaccinated population! Gene Sequencing [Nature Sub-Journal] The largest DNAm gene study to date: the study of genetic mutations related to DNAm at 420,509 DNAm loci in the blood has been identified.
[Heavyweight] Johns Hopkins University scientists have discovered genetic The self-correction function can resist blood cancer, which is expected to be a major breakthrough in the treatment of blood cancer! Genetic testing [Nature Sub-Journal] The 1.
5 million largest genome-wide association study has identified nearly 600 gene loci related to anti-social behavior, alcoholism, and opioid addiction.
The new coronavirus [Nature] is a heavyweight! Why can the delta mutant virus spread so quickly and fiercely? Scientists from the University of Cambridge take you to learn about its recommendations and activities The 3rd Shanghai International Cancer Conference The 5th Symposium on Modern Clinical Molecular Diagnosis