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This article is original by Translational Medicine Network.
Please indicate the source for reprinting.
Author: Ashley Introduction: Gastric cancer is still one of the most common and deadly cancers in the world, and the search for the development of a treatment method for gastric cancer has never stopped
.
Recently, researchers have successfully established a mouse model whose gastric cancer is very similar to advanced human gastric cancer
.
Using this model, they discovered gastric cancer stem cells that are critical to the development, maintenance and metastasis of cancer, namely Lgr5+ gastric cancer cells
.
And this research provides an experimental system that can perform detailed analysis of highly malignant gastric cancer, which is expected to develop a breakthrough treatment method for advanced human gastric cancer
.
In Japan, about one million people are newly diagnosed with cancer every year
.
Gastric cancer is the third leading cause of cancer deaths.
Every year, more than 40,000 Japanese die from gastric cancer
.
Advanced gastric cancer is chemotherapy with anticancer drugs, but there is still no completely effective treatment method
.
One reason is that there is currently no mouse model that can replicate the occurrence and malignant transformation of human gastric cancer in vivo
.
Therefore, even now, the mechanism of gastric cancer occurrence and malignancy is not fully understood, and effective treatment methods for malignant gastric cancer have not yet been established
.
Recently, the existence of cancer stem cells is considered to be one of the reasons why malignant cancers exhibit drug resistance
.
Cancer stem cells have pluripotency and self-renewal ability
.
Even if the surrounding cancer cells disappear after chemotherapy, the stem cells will survive and regenerate cancer cells, leading to cancer recurrence
.
However, until now, the existence of cancer stem cells has not been clearly established, so there has not been a detailed analysis of gastric cancer stem cells
.
Therefore, for the development of effective treatments for malignant gastric cancer, it is necessary to establish a mouse model that is very similar to human gastric cancer, to clarify the malignant mechanisms that cause invasion and metastasis in the body, and to take into account the characteristics of gastric cancer stem cells present in gastric cancer tissues.
Including its interaction with the surrounding microenvironment
.
Recently published in "Nature Cell Biology", an article entitled "A tumour-resident Lgr5+ stem-cell-like pool drives the establishment and progression of advanced gastric cancers" found that it is essential for the development, maintenance and metastasis of cancer.
The important gastric cancer stem cells are Lgr5+ gastric cancer cells
.
And this research provides an experimental system that can perform detailed analysis of highly malignant gastric cancer, which is expected to develop a breakthrough treatment method for advanced human gastric cancer
.
This research was conducted by an international research team composed of scientists from the Epithelial Stem Cell Biology Department of Kanazawa University Cancer Institute and scientists from Singapore’s A*Star Research Bureau
.
The research team newly established Cldn18-IRES-CreERT2 mice that can selectively induce gastric epithelial mutations
.
By crossing these with mice that can induce mutations in a WNT signaling gene and a RAS signaling gene or Trp53 gene (as reported in the TCGA Gastric Cancer Database), the research team successfully developed a new gastric cancer mouse model.
Can replicate human metastatic gastric cancer
.
Through detailed comparison and analysis of gastric cancer tissues produced by these mice and patients’ gastric cancer tissues, it was confirmed that the characteristics and gene expressions observed in human advanced gastric cancer were accurately reproduced
.
This shows that their newly established mouse model of gastric cancer can be a valuable resource for basic and preclinical research on gastric cancer
.
In addition, by orthotopic transplantation of organoids established from mouse gastric cancer tissues into the mouse stomach, the research team developed an orthotopic transplantation model that reproduced the metastasis process of gastric cancer, which can perform large-scale, rapid, and highly reproducible Sexual analysis
.
Through detailed analysis using these models, the research team found that gastric cancer cells expressing the Lgr5 gene, known as the target gene of Wnt signaling, play an important role in the occurrence and development of gastric cancer
.
At the same time, by studying the contribution of Lgr5+ gastric cancer cells to gastric cancer metastasis, using a drug that eliminates Lgr5+ gastric cancer cells in the body, they revealed that Lgr5+ gastric cancer cells are actually gastric cancer stem cells necessary for gastric cancer metastasis
.
Furthermore, they have determined that by using the anticancer drug 5-fluorouracil to remove Lgr5+ gastric cancer stem cells, it can effectively inhibit the progression and metastasis of gastric cancer in the body
.
This study revealed that Lgr5+ gastric cancer stem cells play an important role in the occurrence, development and metastasis of gastric cancer
.
In addition, it has been clarified that the synergistic effect of an anticancer drug and the removal of gastric cancer stem cells can significantly inhibit the progression and metastasis of gastric cancer
.
The results of the study show that the development of a therapeutic method that targets Lgr5+ gastric cancer cells also present in human gastric cancer tissue has great clinical significance
.
Furthermore, the new mouse model of gastric cancer established by the team may be suitable for elucidating the mechanism of gastric cancer occurrence, development and metastasis, screening new diagnostic and therapeutic drugs, and preclinical research
.
Further research will help to develop an effective method for the treatment of metastatic gastric cancer by targeting gastric cancer stem cells
.
Reference materials: https://medicalxpress.
com/news/2021-12-gastric-cancer-identification-stem-cells.
html Note: This article aims to introduce medical research progress and cannot be used as a reference for treatment options
.
If you need health guidance, please go to a regular hospital for treatment
.
Recommendation·Activity [Live Preview] New CRISPR technology combined with high-efficiency electrotransformation technology to help gene editing experience sharing, action knowledge practitioners-Single-cell Scientific Research Creation Camp (Wuhan Station) Popular·Article Basic Research [Science Sub-Journal] Transforming Artificial Lung-Lizard Provides an amazing method! Intestinal flora [Nature] Did you take hypoglycemic drugs ineffective? Because the intestinal microflora is in the process of cancer treatment [PNAS] Chinese medicinal materials thyme and oregano have found anti-cancer compounds for disease diagnosis and treatment [Nature Sub-Journal] This is another step towards changing the US$70 billion global diagnostic industry! Protein biosensors can measure toxic drugs for cardiovascular disease in cancer, arthritis, and organ transplant patients [JAMA Sub-Journal] Are you stressed? Stress increases the risk of cardiovascular disease! Scientific research [Cell Sub-Journal] Why do pain and anxiety speed up the breathing rate? The scientific research "Science" announced the breakthrough of 2021: A problem that has troubled biologists for 50 years was solved by AI and realized the dream of a Nobel Prize winner!
Please indicate the source for reprinting.
Author: Ashley Introduction: Gastric cancer is still one of the most common and deadly cancers in the world, and the search for the development of a treatment method for gastric cancer has never stopped
.
Recently, researchers have successfully established a mouse model whose gastric cancer is very similar to advanced human gastric cancer
.
Using this model, they discovered gastric cancer stem cells that are critical to the development, maintenance and metastasis of cancer, namely Lgr5+ gastric cancer cells
.
And this research provides an experimental system that can perform detailed analysis of highly malignant gastric cancer, which is expected to develop a breakthrough treatment method for advanced human gastric cancer
.
In Japan, about one million people are newly diagnosed with cancer every year
.
Gastric cancer is the third leading cause of cancer deaths.
Every year, more than 40,000 Japanese die from gastric cancer
.
Advanced gastric cancer is chemotherapy with anticancer drugs, but there is still no completely effective treatment method
.
One reason is that there is currently no mouse model that can replicate the occurrence and malignant transformation of human gastric cancer in vivo
.
Therefore, even now, the mechanism of gastric cancer occurrence and malignancy is not fully understood, and effective treatment methods for malignant gastric cancer have not yet been established
.
Recently, the existence of cancer stem cells is considered to be one of the reasons why malignant cancers exhibit drug resistance
.
Cancer stem cells have pluripotency and self-renewal ability
.
Even if the surrounding cancer cells disappear after chemotherapy, the stem cells will survive and regenerate cancer cells, leading to cancer recurrence
.
However, until now, the existence of cancer stem cells has not been clearly established, so there has not been a detailed analysis of gastric cancer stem cells
.
Therefore, for the development of effective treatments for malignant gastric cancer, it is necessary to establish a mouse model that is very similar to human gastric cancer, to clarify the malignant mechanisms that cause invasion and metastasis in the body, and to take into account the characteristics of gastric cancer stem cells present in gastric cancer tissues.
Including its interaction with the surrounding microenvironment
.
Recently published in "Nature Cell Biology", an article entitled "A tumour-resident Lgr5+ stem-cell-like pool drives the establishment and progression of advanced gastric cancers" found that it is essential for the development, maintenance and metastasis of cancer.
The important gastric cancer stem cells are Lgr5+ gastric cancer cells
.
And this research provides an experimental system that can perform detailed analysis of highly malignant gastric cancer, which is expected to develop a breakthrough treatment method for advanced human gastric cancer
.
This research was conducted by an international research team composed of scientists from the Epithelial Stem Cell Biology Department of Kanazawa University Cancer Institute and scientists from Singapore’s A*Star Research Bureau
.
The research team newly established Cldn18-IRES-CreERT2 mice that can selectively induce gastric epithelial mutations
.
By crossing these with mice that can induce mutations in a WNT signaling gene and a RAS signaling gene or Trp53 gene (as reported in the TCGA Gastric Cancer Database), the research team successfully developed a new gastric cancer mouse model.
Can replicate human metastatic gastric cancer
.
Through detailed comparison and analysis of gastric cancer tissues produced by these mice and patients’ gastric cancer tissues, it was confirmed that the characteristics and gene expressions observed in human advanced gastric cancer were accurately reproduced
.
This shows that their newly established mouse model of gastric cancer can be a valuable resource for basic and preclinical research on gastric cancer
.
In addition, by orthotopic transplantation of organoids established from mouse gastric cancer tissues into the mouse stomach, the research team developed an orthotopic transplantation model that reproduced the metastasis process of gastric cancer, which can perform large-scale, rapid, and highly reproducible Sexual analysis
.
Through detailed analysis using these models, the research team found that gastric cancer cells expressing the Lgr5 gene, known as the target gene of Wnt signaling, play an important role in the occurrence and development of gastric cancer
.
At the same time, by studying the contribution of Lgr5+ gastric cancer cells to gastric cancer metastasis, using a drug that eliminates Lgr5+ gastric cancer cells in the body, they revealed that Lgr5+ gastric cancer cells are actually gastric cancer stem cells necessary for gastric cancer metastasis
.
Furthermore, they have determined that by using the anticancer drug 5-fluorouracil to remove Lgr5+ gastric cancer stem cells, it can effectively inhibit the progression and metastasis of gastric cancer in the body
.
This study revealed that Lgr5+ gastric cancer stem cells play an important role in the occurrence, development and metastasis of gastric cancer
.
In addition, it has been clarified that the synergistic effect of an anticancer drug and the removal of gastric cancer stem cells can significantly inhibit the progression and metastasis of gastric cancer
.
The results of the study show that the development of a therapeutic method that targets Lgr5+ gastric cancer cells also present in human gastric cancer tissue has great clinical significance
.
Furthermore, the new mouse model of gastric cancer established by the team may be suitable for elucidating the mechanism of gastric cancer occurrence, development and metastasis, screening new diagnostic and therapeutic drugs, and preclinical research
.
Further research will help to develop an effective method for the treatment of metastatic gastric cancer by targeting gastric cancer stem cells
.
Reference materials: https://medicalxpress.
com/news/2021-12-gastric-cancer-identification-stem-cells.
html Note: This article aims to introduce medical research progress and cannot be used as a reference for treatment options
.
If you need health guidance, please go to a regular hospital for treatment
.
Recommendation·Activity [Live Preview] New CRISPR technology combined with high-efficiency electrotransformation technology to help gene editing experience sharing, action knowledge practitioners-Single-cell Scientific Research Creation Camp (Wuhan Station) Popular·Article Basic Research [Science Sub-Journal] Transforming Artificial Lung-Lizard Provides an amazing method! Intestinal flora [Nature] Did you take hypoglycemic drugs ineffective? Because the intestinal microflora is in the process of cancer treatment [PNAS] Chinese medicinal materials thyme and oregano have found anti-cancer compounds for disease diagnosis and treatment [Nature Sub-Journal] This is another step towards changing the US$70 billion global diagnostic industry! Protein biosensors can measure toxic drugs for cardiovascular disease in cancer, arthritis, and organ transplant patients [JAMA Sub-Journal] Are you stressed? Stress increases the risk of cardiovascular disease! Scientific research [Cell Sub-Journal] Why do pain and anxiety speed up the breathing rate? The scientific research "Science" announced the breakthrough of 2021: A problem that has troubled biologists for 50 years was solved by AI and realized the dream of a Nobel Prize winner!
