Nature Sub-Journal: Yeast "transformed" engineering probiotics can be used to treat inflammatory bowel disease

Inflammatory bowel disease (IBD) is a complex chronic inflammatory disease of the gastrointestinal tract, including Crohn's disease and ulcerative colitis

Symbiotic microbiota is a hot topic in current medical research.

On June 28, 2021, the Francisco J.

DOI: 10.

Yeast is widely used in food.

Directed evolution of human P2Y2 receptor

Subsequently, in order to allow probiotics to sense and neutralize pro-inflammatory molecules, the researchers linked the activation of this engineered P2Y2 receptor to the secretion of adenosine triphosphate bisphosphatase, adenosine triphosphate bisphosphatase.

Engineered yeast secretes eAtP in response to AtPase

Finally, the researchers evaluated the viability of engineered yeast in the digestive tract of mice and the therapeutic value of engineered yeast administered orally in different colitis models

eATP reactive engineering yeast improves chemically induced colitis

In summary, this research created engineered yeast probiotics that can sense pro-inflammatory molecules and produce a self-regulating response to the ratio of neutralizing pro-inflammatory molecules.

Reference materials:

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