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This article is the original of the translational medicine network, please indicate the source when reprinting
Author: Sophia
Photodynamic therapy (PDT), a less invasive clinical cancer treatment strategy, shows great potential
Recently, the team led by Huang Wei, academician of the Chinese Academy of Sciences, and An Zhongfu, professor of Nanjing University of Technology, and the research group of Professor Chen Hongmin of Xiamen University cooperated to publish the paper "Organic phosphorescent nanoscintillator for low-dose X-ray-induced photodynamic therapy" in Nature Communications, using pure organic phosphorescent scintillators , to achieve efficient photodynamic therapy
background
01
X-ray-induced photodynamic therapy uses X-rays to activate reactive oxygen species in deep tissues for cancer treatment, combining the advantages
Research progress
02
The research team achieved radiosensitivity by introducing heavy atoms, using heavy atoms and elements such as nitrogen and oxygen containing solitary pairs of electrons to promote interlineage channeling between the monomeric and trilinear states, thereby promoting the generation of trilinear excitons, and preparing a photosensitizer that can directly use X-rays, and combining the scintillator and the photosensitizer into one
"Unlike the traditional strategy of using X-ray excitation scintillators as an energy medium and relying on energy transfer between scintillators and photosensitizers, our pure organic phosphorescent scintillator materials can both directly absorb X-rays and act as photosensitizers
Schematic diagram of X-PDT based on organophosphorescent nanoscintillator
Research implications
03
In this work, the researchers elucidated the X-PDT mechanism
This discovery demonstrates the great potential
Resources:
This article is intended to introduce medical research advances and cannot be used as a reference for
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