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    Home > Active Ingredient News > Antitumor Therapy > 【Nature sub-journal】Academician Huang Wei of the Chinese Academy of Sciences and the team of Professor An Zhongfu/Chen Hongmin found that phosphorescence scintillators can help treat deep tumors

    【Nature sub-journal】Academician Huang Wei of the Chinese Academy of Sciences and the team of Professor An Zhongfu/Chen Hongmin found that phosphorescence scintillators can help treat deep tumors

    • Last Update: 2022-10-01
    • Source: Internet
    • Author: User
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    This article is the original of the translational medicine network, please indicate the source when reprinting

    Author: Sophia

    Photodynamic therapy (PDT), a less invasive clinical cancer treatment strategy, shows great potential


    Recently, the team led by Huang Wei, academician of the Chinese Academy of Sciences, and An Zhongfu, professor of Nanjing University of Technology, and the research group of Professor Chen Hongmin of Xiamen University cooperated to publish the paper "Organic phosphorescent nanoscintillator for low-dose X-ray-induced photodynamic therapy" in Nature Communications, using pure organic phosphorescent scintillators , to achieve efficient photodynamic therapy


    background

     01 

    X-ray-induced photodynamic therapy uses X-rays to activate reactive oxygen species in deep tissues for cancer treatment, combining the advantages


    Research progress

     02 

    The research team achieved radiosensitivity by introducing heavy atoms, using heavy atoms and elements such as nitrogen and oxygen containing solitary pairs of electrons to promote interlineage channeling between the monomeric and trilinear states, thereby promoting the generation of trilinear excitons, and preparing a photosensitizer that can directly use X-rays, and combining the scintillator and the photosensitizer into one


    "Unlike the traditional strategy of using X-ray excitation scintillators as an energy medium and relying on energy transfer between scintillators and photosensitizers, our pure organic phosphorescent scintillator materials can both directly absorb X-rays and act as photosensitizers


    Schematic diagram of X-PDT based on organophosphorescent nanoscintillator

    Research implications

     03 

    In this work, the researchers elucidated the X-PDT mechanism


    This discovery demonstrates the great potential


    Resources:


    This article is intended to introduce medical research advances and cannot be used as a reference for


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