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NATURE: Subversion!

 Last Update: 2021-04-17
 Source: Internet
 Author: User

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Previous studies have generally shown that tumors consume large amounts of glucose and produce lactate in the presence of oxygen.

immunity

The impaired metabolism of immune cells in the tumor microenvironment (TME) helps tumor cells to escape immunity.

Recently, researchers have used PET tracers to measure the utilization and uptake of glucose and glutamine in TME by specific cell subgroups.

Myeloid cells have the strongest ability to take up glucose in the tumor environment, followed by T cells and cancer cells.

Glucose is preferentially consumed by immune cells, not cancer cells.

mTORC1 signal, and the expression of genes related to glucose and glutamine metabolism mTORC1 signal, and the expression of genes related to glucose and glutamine metabolism

Therefore, the internal processes of cells drive immune cells and cancer cells to preferentially obtain glucose and glutamine, respectively.

Used to develop tumor therapies and imaging strategies Used to develop tumor therapies and imaging strategies

Original source:

Bradley I.

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Sub-Journal of "Nature": Subversion of Cognition!

11-16

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NATURE: Subversion!

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Sub-Journal of "Nature": Subversion of Cognition!