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    Home > Active Ingredient News > Immunology News > Nature: T cells also need "early education". As long as the bacteria are taught well, the body's immunity will not be bad!

    Nature: T cells also need "early education". As long as the bacteria are taught well, the body's immunity will not be bad!

    • Last Update: 2021-05-21
    • Source: Internet
    • Author: User
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    The ancients said that "the first to keep in good health is to raise the intestines", and "the intestines live long.


    Recently, from Matthew L.


    Thymic development of gut-microbiota-specific T cells

    To study the influence of intestinal flora on thymus-specific T cells, the researchers used commensal microbial segmented filamentous bacteria (SFB).


    Intestinal microbes can pass through mesenteric lymph nodes (MLNs), but it is not clear what tissues and organs these microbes can reach.


    Increased bacterial-specific T cells in the thymus

    Increased bacterial-specific T cells in the thymus Increased bacterial-specific T cells in the thymus

    Next, the researchers found that the use of antibiotics during weaning of mice can reduce the intestinal flora and reduce the number of dendritic cells in the thymus.


    Symbiotic microorganisms can cause CX3CR1 + DC enrichment in the thymus

    Symbiotic microorganisms can cause CX3CR1 + DC enrichment in the thymus Symbiotic microorganisms can cause CX3CR1 + DC enrichment in the thymus

    Finally, the researchers used a colitis T cell transplantation model to analyze the effects of thymus-specific T cells on peripheral tissues.


    Thymic microbiota-specific T cells play a role in distal tissues

    Thymic microbiota-specific T cells play a role in distal tissues Thymic microbiota-specific T cells play a role in distal tissues

    In general, the study found that in young mice, intestinal microbes migrate to the thymus through intestinal dendritic cells, thereby inducing the expansion of specific T cells in the thymus and synergistically with the intestinal microbes.


    Original source:

    Original source:

    Zegarra-Ruiz, DF, Kim, DV, Norwood, K.


    Thymic development of gut-microbiota-specific T cells.
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