According to the latest global cancer burden data released by the International Agency for Research on Cancer ( IARC ) of the World Health Organization in 2020 , 9.
96 million cancer deaths worldwide will be reported in 2020 .
It is estimated that cancer metastasis causes 90% of the deaths, that is to say, about 9 million people die from cancer metastasis every year in the world .
96 million cancer deaths worldwide will be reported in 2020 .
It is estimated that cancer metastasis causes 90% of the deaths, that is to say, about 9 million people die from cancer metastasis every year in the world .
Fatty acid intake and metabolic changes have always been thought to be related to cancer metastasis, which refers to the process by which cancer cells spread to other parts of the body
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However, which dietary fatty acids may lead to cancer metastasis, and the biological mechanisms in it have been awaiting research
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However, which dietary fatty acids may lead to cancer metastasis, and the biological mechanisms in it have been awaiting research
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Palm oil is a kind of vegetable oil extracted from palm fruit of the tropical woody plant oil palm tree.
It is currently the world’s largest vegetable oil variety in terms of production, consumption and international trade.
It is also called " world's three major vegetable oil " , has more than five thousand years of history edible
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China is the world's largest importer of palm oil, and its annual consumption of palm oil is about 6 million tons, accounting for 20% of the total market
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It is currently the world’s largest vegetable oil variety in terms of production, consumption and international trade.
It is also called " world's three major vegetable oil " , has more than five thousand years of history edible
.
China is the world's largest importer of palm oil, and its annual consumption of palm oil is about 6 million tons, accounting for 20% of the total market
.
2021 Nian 11 Yue 10 days, the researchers agency in Barcelona, Spain Science and Technology, Northwestern University, in Nature published a report entitled: Dietary palmitic acid promotes prometastatic A Memory Via Schwann cells research papers
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The study found that when palmitic acid is supplemented in the diet of mice, it not only promotes cancer metastasis, but also has a long-term effect on the genome
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Even if palmitic acid is removed from the diet, cancer cells that have only been exposed to palmitic acid in the diet for a short period of time still maintain a high degree of metastasis
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Even if palmitic acid is removed from the diet, cancer cells that have only been exposed to palmitic acid in the diet for a short period of time still maintain a high degree of metastasis
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Based on this discovery, the research team has developed a therapy to block cancer cell metastasis, and is expected to launch human clinical trials in the next few years
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First, researchers exposed human oral cancer and melanoma cells to one of three dietary fatty acids — palmitic acid (the main saturated fatty acid in palm oil), oleic acid, or linoleic acid — for a period of four.
Days later, these cells were transplanted into the corresponding tissues of mice fed a standard diet
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Although all the fatty acids in the study had no effect on tumorigenesis, palmitic acid significantly increased the invasiveness and size of existing metastases
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No such significant effects were observed in oleic acid or linoleic acid
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Days later, these cells were transplanted into the corresponding tissues of mice fed a standard diet
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Although all the fatty acids in the study had no effect on tumorigenesis, palmitic acid significantly increased the invasiveness and size of existing metastases
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No such significant effects were observed in oleic acid or linoleic acid
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Metastasis-promoting cancer cells also retain the " memory " of exposure to high concentrations of palmitic acid
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For example, tumors of mice fed a diet rich in palm oil for only ten days, or tumor cells that were briefly exposed to palmitic acid for four days in the laboratory (and then put back into normal medium), even if transplanted to a normal diet In mice, it still has a high degree of metastasis
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And this process requires the fatty acid transporter CD36 , and is related to the stable deposition of lysine trimethylation ( H3K4me3 ) at position 4 on histone H3 mediated by the methyltransferase Set1A .
This epigenetic change changes the pattern of gene expression without changing the DNA sequence itself, thereby mediating the long-term stimulation of metastasis .
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For example, tumors of mice fed a diet rich in palm oil for only ten days, or tumor cells that were briefly exposed to palmitic acid for four days in the laboratory (and then put back into normal medium), even if transplanted to a normal diet In mice, it still has a high degree of metastasis
.
And this process requires the fatty acid transporter CD36 , and is related to the stable deposition of lysine trimethylation ( H3K4me3 ) at position 4 on histone H3 mediated by the methyltransferase Set1A .
This epigenetic change changes the pattern of gene expression without changing the DNA sequence itself, thereby mediating the long-term stimulation of metastasis .
This " memory " of cancer metastasis is caused by epigenetic changes.
Epigenetic changes change the function of metastatic cancer cells, allowing them to form a neural network around the tumor, communicate with cells in the surrounding environment and make changes.
Easy to spread
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By understanding the nature of this communication, the research team has discovered a way to stop it, and is now planning a clinical trial to prevent the metastasis of different types of cancer
.
Epigenetic changes change the function of metastatic cancer cells, allowing them to form a neural network around the tumor, communicate with cells in the surrounding environment and make changes.
Easy to spread
.
By understanding the nature of this communication, the research team has discovered a way to stop it, and is now planning a clinical trial to prevent the metastasis of different types of cancer
.
The drug being developed for clinical trials is an antibody developed by ONA Therapeutics , which was co-founded by Professor Salvador Aznar-Benitah ,
the corresponding author of the paper .
It is reported that the company recently received 30 million euros from private investors for the development of treatments for this metastatic cancer
.
It is expected that human clinical trials will be carried out in the next few years
.
the corresponding author of the paper .
It is reported that the company recently received 30 million euros from private investors for the development of treatments for this metastatic cancer
.
It is expected that human clinical trials will be carried out in the next few years
.
Overall, this study provides evidence that dietary metabolites induce stable transcription and chromatin changes, leading to long-term stimulation of metastasis, and this is consistent with the regeneration status of tumor-activated Schwann cells .
Related
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Related
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The research team also stated that this discovery is a huge breakthrough in our understanding of the connection between diet and cancer.
More importantly, this knowledge can be used to open new cancer treatments
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More importantly, this knowledge can be used to open new cancer treatments
.
Paper link:
Paper link:https:// class="s1" >https://
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