Nature: The fatty acids in this widely consumed vegetable oil will promote cancer metastasis

According to the latest global cancer burden data released by the International Agency for Research on Cancer ( IARC ) of the World Health Organization in 2020 , 9.

According to the latest global cancer burden data released by the International Agency for Research on Cancer ( IARC ) of the World Health Organization in 2020 , 9.

Fatty acid intake and metabolic changes have always been thought to be related to cancer metastasis, which refers to the process by which cancer cells spread to other parts of the body

Fatty acid intake and metabolic changes have always been thought to be related to cancer metastasis, which refers to the process by which cancer cells spread to other parts of the body

Palm oil is a kind of vegetable oil extracted from palm fruit of the tropical woody plant oil palm tree.

2021 Nian 11 Yue 10 days, the researchers agency in Barcelona, Spain Science and Technology, Northwestern University, inNaturepublished a report entitled: Dietary palmitic acid promotes prometastatic A Memory Via Schwann cellsresearch papers

The study found that when palmitic acid is supplemented in the diet of mice, it not only promotes cancer metastasis, but also has a long-term effect on the genome

Based on this discovery, the research team has developed a therapy to block cancer cell metastasis, and is expected to launch human clinical trials in the next few years

First, researchers exposed human oral cancer and melanoma cells to one of three dietary fatty acids — palmitic acid (the main saturated fatty acid in palm oil), oleic acid, or linoleic acid — for a period of four.

First, researchers exposed human oral cancer and melanoma cells to one of three dietary fatty acids — palmitic acid (the main saturated fatty acid in palm oil), oleic acid, or linoleic acid — for a period of four.

Metastasis-promoting cancer cells also retain the " memory " of exposure to high concentrations of palmitic acid

This " memory " of cancer metastasis is caused by epigenetic changes.

The drug being developed for clinical trials is an antibody developed byONA Therapeutics  , which was co-founded by Professor  Salvador Aznar-Benitah  ,

Overall, this study provides evidence that dietary metabolites induce stable transcription and chromatin changes, leading to long-term stimulation of metastasis, and this is consistent with the regeneration status of tumor-activated Schwann cells .

The research team also stated that this discovery is a huge breakthrough in our understanding of the connection between diet and cancer.

Paper link:

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