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TBG is safer than Iberg alkali, pictured from Nature, 2020, doi:10.1038/s41586-020-3008-z.
, an assistant professor of chemistry at the University of California, Davis, said, "Psychedelics are the most powerful drug we know to affect the brain, and we know incredibly little about it."
" is extracted from the plant Tabernanthe iboga, which is said to have powerful anti-addiction effects such as reducing drug cravings and preventing the recurrence of addiction.
also have serious side effects, including hallucinations and heart toxicity.
drug is one of the controlled substances of the relevant national authorities under United States law.
Olson's lab at the University of California, Davis, is one of the few in the United States to be allowed to use Schedule 1 substances.
they set out to build a synthetic similar to the Iberg alkali, which retains both therapeutic properties and the adverse effects of the psychedelic compound.
Olson team studied a series of similar compounds by replacing some of the components of the Iberg alkali molecule.
they designed a new synthetic molecule and named it tabernanthalog (TBG).
models of anxiety, depression, and addiction, unlike Iberg base, this new molecule is water-soluble and can be synthesized in one step.
using cell cultures and zebrafish showed that it was less toxic than Iberg alkali, which can cause heart attacks and has killed several people.
TBG can increase the formation of new synapses (branches) in rat nerve cells, as well as the formation of new synapses (spine) on these synapses.
This is similar to the effects of drugs such as ketamine, ketamine, methyl diethylamine (LSD), 3,4-MDMA, and dmethylamine (DMT, an active ingredient in plant extract dead rattan water) on connections between nerve cells.
, however, TBG did not cause convulsions in the mice's heads.
, this head convulsion reaction is associated with human hallucinations.
series of experiments in rodent models of depression and addiction have shown that the new drug has the hope of having a positive effect.
these animal models --- are conducted in accordance with national health system (NIH) regulations and reviewed and approved by the Institutional Animal Management and Use Committee--- remain critical to investigating complex mental illnesses.
were trained to drink reduced their intake after taking a dose of TBG.
rats were trained to link light and pitch to pressing levers to obtain heroin.
when the opiate was taken away, the rats showed signs of withdrawal and pressed the lever again at the prompting of light and sound.
the rats with TBG, the results showed a long-term inhibitory effect on the recurrence of addiction to the opiate.
Olson believes TBG works by altering the structure of neurons in key brain circuits involved in depression, anxiety, post-traumatic stress disorder and addiction.
, "We've been focusing on treating a mental illness at once, but we know there's overlap between these diseases," Olson said.
may be able to treat a variety of diseases with the same drug.
," he said, "we need a drug that people can put in the medicine box, and that's an important step in that direction."
" In fact, psychedelic therapy has been attracting new interest in recent years.
, personal "trips" with patients can be time-and-money, requiring hours of close medical supervision in addition to possible negative effects.
: 1.Lindsay P. Cameron et al. A non-hallucinogenic psychedelic analogue with therapeutic potential. Nature, 2020, doi:10.1038/s41586-020-3008-z. 2.New compound related to psychedelic ibogaine could treat addiction, depression 3.Psychedelics re-engineered for potential use in the clinic。