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    Home > Active Ingredient News > Study of Nervous System > Nature: "The Star's Child" Sees the Light Again! Wake up the "common gene" Nlgn3, or cure autism.

    Nature: "The Star's Child" Sees the Light Again! Wake up the "common gene" Nlgn3, or cure autism.

    • Last Update: 2020-09-03
    • Source: Internet
    • Author: User
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    Autism, also known as autism, is a developmental disorder that affects communication and behavior.
    people with autism are often reluctant to look at people, do not want to communicate with people, always immersed in their own piece of starry sky, and therefore often referred to as "star children."
    oxytocin (OXT) is a hormone and neurotransmitter that, in addition to promoting uterine contraction, is involved in the building of relationships, trust, sexual activity and intimacy.
    years, the relationship between OXT and autism has become a hot topic of research.
    previous studies have found that social dysfunction in people with autism may stem from lower levels of oxytocin in the body.
    since oxytocin is so closely related to autism, can we further study the underlying causes of autism on this basis? and find further potential treatments for autism? Researchers at the University of Basel's Centre for Biology recently published an article in Nature entitled "Rescue of oxytocin and social behaviour in a mouse model of autism", revealing for the first time the neurogligin-3(Neuroligin-3, Mutations in the Nlgn3) gene disrupt the signaling pathways of oxytocin in neurons in the brain reward system by affecting the balance of protein synthesis in neurons in the brain reward system, while the social behavior of animals can be re-normalized using a highly specific brain osmosis inhibitor, MAP kinase interaction kinase (MNK).
    Doi:10.1038/s41586-020-2563-7 Initially, the researchers knocked out the Nlgn3 gene (Nlgn3KO mice) in young mice and asked them to perform a social identification task.
    found that the lack of selectivity in Nlgn3 in neurons reduced the social interaction between Nlgn3KO mice with recognition disorders.
    The lack of reaction esotericity in mice with Nlgn3 caught the researchers' attention, so they studied whether the absence of Nlgn3 affected the effects of these neurons on oxytocin responses by marking the brain abdominal cover (VTA) neurons in the inner shell layer of the NAC.
    results, the baseline discharge frequency of VTA neurons in Nlgn3KO mice was slightly reduced, and the discharge frequency of wild mouse cells was significantly increased by 1μM oxytocin.
    these conditions suggest that "identification disorders" in Nlgn3KO mice are caused by decreased oxytocin levels, and that the absence of Nlgn3 is closely associated with oxytocin neurons and autism.
    the oxytocin response of VTA neurons missing Nlgn3 changed, and the researchers conducted proteomic identification of molecular changes in the central abdominal area (VTA) of Nlgn3KO mice, and found that changes in mRNA translation were associated with deficiencies in neuron plasticity.
    suggests that the loss of Nlgn3 can alter the translation process in mice, and that the destruction of this translational state can lead to damage to neuron plasticity (the ability of neurons to connect) and neurodevelopment.
    the destruction of translation regulation in Nlgn3KO mice VTA, the researchers wondered whether the reaction of oxytocin neurons could be restored by restoring the translation process in Nlgn3KO mice. In further studies, the researchers focused on the effects of ETC-168, a key regulatory factor in the mRNA translation process, on Nlgn3KO mice.
    found that ETC-168 could restore social behavior in mice that had knocked out the Nlgn3 gene, altering their social cognition and becoming healthier.
    ETC-168 restored the social abilities of lgn3KO mice, it is worth noting that ETC-168 is generally better to withstand and can be used for long-term treatment.
    the lack of the Nlgn3 gene reduces the role of oxytocin, which affects the ability of mice to socialize, and the treatment of ETC-168 restores this autistic behavior.
    , this is the "star's child", no doubt brought a ray of hope.
    Of course, we also need to think dialectically about autism, and oxytocin is a susceptible factor to consider, but not the only factor that causes it to develop.
    in addition to genetic factors, such as mental factors, digestive disorders and some post-those factors can lead to autism.
    if we have "lonely people" around us, please don't look at them with colored eyes, please give them the same respect.
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