NATURE: Whole genome sequencing found that there is a large number of repeated DNA sequences in autism?

!---- The size and sequence of tandem DNA repetition are different in size and sequence at each cell (motif).increased tandem DNA has been linked to more than 40 monogene diseases., however, to date, much of how they are involved in complex diseases remains unknown.here, researchers surveyed the genomes of 17,231 autistic families and control groups with series-repeated whole genome characteristics with 2-20-bp base sequences.researchers have found broad polymorphisms in base sequence sizes and sequences. manyare associated with weak sites of cytogenetics., 2,588 sites had a younger, genetic-related repeat sequence amplification, which was significantly more common in people with autism than their unaffected siblings, which were rare in the control group. In addition,, the increase in these repeated sequences is found in the vicinity of exosomes and shearing points, as well as in genes associated with nervous system development and cardiovascular systems or muscles.the probability of a rare series of repeated amplifications in children with autism was 23.3 percent, compared with 20.7 percent among unaffected children, indicating a 2.6 percent collective contribution to the risk of autism.they include known neuromuscular disease-related DMPK and FXN, as well as repeated autism-related repeated amplification at new sites such as FGF14 and CACNB1.these are all related to lower IQs and adaptability., the results reveal the dramatic impact of repeated amplification of tandem DNA on the genetic causes and phenotype complexity of autism..