Nature: Why does chronic stress make people "bald"

Stem cells are regulated by both internal regulators and external signals.

Recently, in order to understand the mechanism that connects systemic changes and stem cell behavior, researchers have explored the effects of chronic stress on hair follicle stem cells.

Chronic stress is suspected to be related to human hair loss.

Removal of adrenal glands can activate hair follicle stem cells

Recently, researchers have discovered that in the absence of systemic corticosterone, the number of hair follicle stem cells entering the regenerative cycle during the whole life process is greatly increased.

In terms of mechanism, corticosterone acts on the dermal papilla and inhibits the expression of Gas6, which is a gene encoding the secreted factor growth arrest specific 6.

Therefore, this research has determined that corticosterone is a systemic inhibitor of hair follicle stem cell activity through the influence of corticosterone on the microenvironment of hair follicle stem cells, and proved that the removal of this inhibition will prompt hair follicle stem cells to enter frequent regeneration cycles, and this There are no obvious shortcomings in the treatment method in the long run.

Original source:

Sekyu Choi et al.