echemi logo
Product
  • Product
  • Supplier
  • Inquiry
    Home > Biochemistry News > Biotechnology News > Nature: Widespread brain receptor hides surprising mechanism of action

    Nature: Widespread brain receptor hides surprising mechanism of action

    • Last Update: 2022-05-17
    • Source: Internet
    • Author: User
    Search more information of high quality chemicals, good prices and reliable suppliers, visit www.echemi.com

    The findings, published April 20 in the journal Nature, may aid the development of a new generation of more effective neurological and psychiatric treatments with fewer side effects
    .

    The new study took a deep dive into the brain's most prevalent neurotransmitter, glutamate
    .
    Glutamate binds to receptors on brain cells, opening a channel into the cell, allowing ions to pass through, propagating electrical signals

    .

    "The way the brain works is through communication between neurons, and these are the main receptors that allow this communication," said Alexander Sobolev, associate professor of biochemistry and molecular biophysics at Columbia University and senior author of the paper.
    Dr.
    Ski said

    .

    Each receptor can bind up to four molecules of glutamate and produce four different levels of conductivity
    .
    Previous studies linked binding to conductivity in a simple step-by-step fashion, with each additional glutamate molecule bound, the conductivity increased further

    .

    While this explanation makes sense, no one has looked closely to confirm it
    .
    In the new work, the researchers combined cryo-electron microscopy techniques and sophisticated data analysis to reveal, for the first time, a detailed picture of glutamate binding to the receptor

    .

    "We actually ran the experiments under conditions where we saw all these intermediates, one glutamate, two glutamate, three glutamate, and then all four bound in," Sobolevski said.
    together

    .
    "

    These images show that glutamate only binds to subunits of the receptor in a specific way
    .
    This overturns the commonly held belief that each subunit binds glutamate individually, and points to the complexity of neuronal signaling and drug responses

    .

    Rather than a direct step-by-step transition, Sobolevsky and his colleagues found that the glutamate molecule must first bind to one of two specific subunits of the receptor before it can bind to the other two
    .
    Furthermore, the conductivity level of a receptor is not directly related to the amount of glutamate bound to it; a receptor can have two or more glutamate and still only reach first-order conductivity levels

    .

    This result opens up a whole new avenue of research, and the team is now exploring how different accessory molecules on neurons affect this interaction
    .
    Knowing more about the specific activation state of glutamate receptors may help develop better drugs to treat glutamate receptor-related disorders such as depression, dementia, Parkinson's, epilepsy and stroke

    .

    Video: https://youtu.
    be/IeQZTFMz5ek

    This research was supported by the National Institutes of Health (R01 CA206573, R01 NS083660, R01 NS107253, R01 AR078814, R01 GM128195, and R01 AG065594) and the National Science Foundation (1818086, 1818213, and 1563291)
    .

    Journal Reference :

    1. Maria V.
      Yelshanskaya, Dhilon S.
      Patel, Christopher M.
      Kottke, Maria G.
      Kurnikova, Alexander I.
      Sobolevsky.
      Opening of glutamate receptor channel to subconductance levels .
      Nature , 2022; DOI: 10.
      1038/s41586-022-04637-w


    This article is an English version of an article which is originally in the Chinese language on echemi.com and is provided for information purposes only. This website makes no representation or warranty of any kind, either expressed or implied, as to the accuracy, completeness ownership or reliability of the article or any translations thereof. If you have any concerns or complaints relating to the article, please send an email, providing a detailed description of the concern or complaint, to service@echemi.com. A staff member will contact you within 5 working days. Once verified, infringing content will be removed immediately.

    Contact Us

    The source of this page with content of products and services is from Internet, which doesn't represent ECHEMI's opinion. If you have any queries, please write to service@echemi.com. It will be replied within 5 days.

    Moreover, if you find any instances of plagiarism from the page, please send email to service@echemi.com with relevant evidence.