"Nature": Within half a year after Covid-19 recovers, the risk of death has soared by more than 50%!

In foreign media reports on the epidemic, the term “Long-Covid” is often seen, which is the so-called “long-term sequelae of the new crown”, and the cases reported by patients are more scary.

The sense of smell and taste are considered mild.
In some reports, patients also say that they have long-term headaches, dizziness, tiredness, baldness.
.
.
and they are troubled by long-term sequelae.
It is not just the patients who were severely ill when infected with the new crown and required hospitalization.
Many Recovered patients with mild to moderate illness and basically relying on self-healing will also suffer from sequelae.

The recent analysis by American scholars of 73,000 mild to moderate COVID-19 patients and 14,000 COVID-19 hospitalized patients has once again suggested the dangers of long-term sequelae: Compared with healthy people who have not been infected with COVID-19, 6 patients with mild to moderate COVID-19 have recovered.
The risk of death within a month has risen by 59%! The sequelae encountered by these mild to moderate patients is very wide, covering many areas such as neurological, cardiovascular, metabolic, and mental diseases.

Compared with hospitalized patients with seasonal flu, the risk of death in hospitalized patients with COVID-19 will also increase by 51% within 6 months of recovery, so COVID-19 is not a "large flu" [1].

The analysis paper has been accepted by Nature.

"Large flu theory" should have no market now, right? (Image source: Pixabay) In fact, as early as the first wave of epidemic peaks in Italy, Spain and other countries subsided in the middle of last year, studies began to focus on the long-term sequelae of the new crown.
For example, an Italian analysis showed that patients had difficulty breathing, fatigue, and Symptoms such as joint pain and chest pain may still persist two months after the infection of the new crown, and the quality of life is also significantly reduced [2].

The data from the United Kingdom in February this year looks even more scary: during the first wave of the epidemic last year, nearly 48,000 patients with new crowns were hospitalized.
Within 5 months after recovery, 30% will be hospitalized again for various reasons, of which 12% He died [3], which is much higher than the historical data of healthy people or patients with other diseases. Therefore, many experts and international organizations have called for attention to the study of the long-term sequelae of COVID-19 patients.
Dr.
Fauci, who served as the U.
S.
government’s anti-epidemic consultant, often uses this to warn the American people to reduce social gatherings and not to "look down on the new crown.
" The long-term threat of
There are too many examples in Europe and the United States that think that the new crown is a scam and then get killed by the new crown (picture source: Pixabay) This time the data provided by American scholars provides a comprehensive analysis of the long-term sequelae of the new crown.

Researchers first based on the U.
S.
Veterans Medical System (VA) database to compare 73,000 patients with mild to moderate illness who were not hospitalized for 30 days after being diagnosed with the new crown, and compared with nearly 5 million healthy veterans who were not infected with the new crown.

From the 30 days after the diagnosis of the new crown to the 6 months of recovery, there were 8.
39 more "excess deaths" out of every 1,000 patients with the new crown than healthy people.

The singularity cakes have mentioned this.
Judging from the data of Iceland, a country that has actually detected all COVID-19 infections (symptomatic + asymptomatic), if the medical system is not tight, the death rate after contracting COVID-19 should be around 0.
5%.

In such a comparison, the excess mortality rate of 0.
84% ​​for mild to moderate patients is even higher! Moreover, these patients did not directly die from the new crown, so they basically do not appear in the epidemic statistics of various countries.
After all, most countries only count deaths within one month after being infected with the new crown, and no longer count them.

The medical record information provided by the database shows that respiratory symptoms such as coughing, dyspnea, and decreased blood oxygen saturation are still the most common problems after recovery.
In addition, headache and other neurological symptoms, hypertension and other cardiovascular symptoms, metabolic diseases, The incidence of mental problems and general discomfort constitutes the "second echelon" of sequelae.

The significantly increased risk of symptoms in COVID-19 patients (left), increased medication use (middle), and abnormal laboratory test results (right) may have more serious effects on long-term sequelae of COVID-19 patients who need to be hospitalized.

The researchers compared 13,600 COVID-19 hospitalized patients with 14,000 influenza inpatients, and found that the excess deaths per 1,000 patients within half a year of recovery reached 28.
79, which is about 3.
5 times that of mild to moderate patients! Inpatients with new crowns are more severely ill when they are sick, so the risk of various sequelae is also higher than that of patients with mild to moderate new crowns or inpatients with influenza.

The researchers also deliberately analyzed the situation of influenza patients from 2017 to 2019 separately and found that after the influenza patients recovered, there were really not so many sequelae or excessive deaths that required medical treatment.

Although the veterans analyzed in this study are mainly elderly men, the conclusions may not necessarily be extrapolated to patients of other ages, genders, and races, but the huge excess death and medical burden cannot be ignored anywhere.

It is indeed necessary for some countries to set up special "outpatient clinics for COVID-19 patients" and "follow-up studies for COVID-19 patients".
After all, it is not yet possible to predict how long the epidemic will last.

It would be better if we could solve the cause of the long-term sequelae as soon as possible from the mechanism level.

Some time ago, Singularity Cake saw the report, saying that some studies hope to cure the long-term sequelae of patients by injecting the new crown vaccine, which is also an option.

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 References: 1.
Al-Aly Z, Xie Y, Bowe B.
High-dimensional characterization of post-acute sequalae of COVID-19 [J].
Nature, 2021.
2.
Carfì A, Bernabei R, Landi F.
Persistent symptoms in patients after acute COVID-19[J].
JAMA, 2020, 324(6): 603-605.
3.
Ayoubkhani D, Khunti K, Nafilyan V, et al.
Post-covid syndrome in individuals admitted to hospital with covid-19: retrospective cohort study[J].
BMJ, 2021, 372.
Source of head picture: KHN.
org Author of this article | Tan Shuo