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New coronavirus mutation has been the focus of attention, in recent times, the United Kingdom, South Africa, Brazil and other countries appear mutants are attracting the attention of global researchers, D614G, N501Y, E484K, P681H and other mutation points are also well known.
these mutations increase the ability of the virus to spread infection, and even some mutations can evade the recognition of the immune system, so people pay more attention to the body's immune system against the new coronavirus, can provide longer protection? A research article entitled "Evolution of antibody immunity to SARS-CoV-2" was recently published in the journal Nature in the form of "Accelerated Preview".
researchers have found that the body's immune system is also evolving.
After the human body is infected with the new coronavirus, the antibody immune response is constantly optimized, neutral antibody specificity is enhanced, the diversity increases, and these antibodies in addition to the effective neutral and new coronavirus, the new coronavirus mutation can also have a protective effect.
followed 100 volunteers for more than six months, 87 of whom met the criteria for analysis.
elisa tested volunteer plasma and found that individuals produced higher, persistent anti-RBD and anti-N protein antibodies.
increased over time (6.2 months), antibody mesoactive activity decreased nearly fivefold, but can still be detected.
cells are the source of circulating antibodies, and memory B cells are the key to immune memory.
researchers' analysis of memory B cell populations found that after 6.2 months of infection, the proportion of memory B cells expressing specific target RBD-IgG antibodies increased significantly in memory B cells, and the soliot of so many cells in memory B cells increased significantly, indicating that the immune system was constantly optimizing the antibody response to the new coronavirus within 1.3 to 6.2 months after infection with the new coronavirus.
cell supermotant is an important manifestation of immune system optimization, by mutations in the anti-weight chain and light chain variable region genes, so that neutral antibody specificity and binding capacity become stronger.
researchers analyzed 1.3-month and 6.2-month monoclonal antibody species and found that monoclonal antibodies significantly increased their ability to match the new coronavirus at 6.2 months.
EC50 value is an indicator of the ability to assess the binding of antibodies, the smaller the value, the stronger the ability to medium.
researchers also looked at the effectiveness of antibodies in a number of new coronavirus gene mutations, including E484K, an important mutation spot found in South Africa and Brazil.
analysis found that among the monoclonal antibodies obtained at 6.2 months, there was a mesoactive activity for these gene mutations that evaded immune identification, so the ability to identify new coronavirus mutants also evolved over time, and the ability to recognize them increased.
evolution of the immune system is related to the screening of B-cells by lymphatic tissue in the center of production, in addition to the super-mutation of soytic cells produced by B cells.
in this study, it was found that the new coronavirus antigen can be in the form of a complex on the surface of the veiled cells for a long time, in order to screen B cells.
may also be that after the patient's symptoms disappear, there are still some viral proteins in the body, these low-level viral proteins can also be used as antigens to screen B cells.
as the saying goes: "Dao is a foot high magic high", in this new coronavirus mutants and the human immune system in the "battle", in the end, the victory? More research is needed.
has developed a series of new coronavirus mutant proteins, which can be used for in-depth study of new coronary mutant strains, as well as new coronary antibodies, vaccine effect evaluation research.
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