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    Home > Active Ingredient News > Immunology News > NCB Chen Liang/Yang Pengyuan and others collaborate to reveal the immune memory mechanism of patients recovering from new coronary pneumonia

    NCB Chen Liang/Yang Pengyuan and others collaborate to reveal the immune memory mechanism of patients recovering from new coronary pneumonia

    • Last Update: 2021-06-22
    • Source: Internet
    • Author: User
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    On June 9, 2021, Nature Cell Biology published an online article titled Single-cell epigenomic landscape of peripheral immune cells reveals establishment of trained immunity in individuals convalescing from COVID-19
    .

    This work uses single-cell ATAC-seq technology and the newly developed single-cell multi-omics Ti-ATAC-seq technology to describe the accessibility of peripheral immune cells to chromatin multi-dimensional atlas in patients recovering from new coronary pneumonia, and to analyze monocytes, The epigenetic mechanism of B cell and T cell immune memory formation
    .

    After certain viral infections or vaccination, the human body can induce natural immune cells to show immune memory characteristics similar to those of adaptive immune cells, that is, "trained immunity"
    .

    The results of the study showed that a large amount of chromatin remodeling occurred in the natural immune cells and adaptive immune cells of patients recovering from new coronary pneumonia
    .

    The peripheral blood of the recovered patients was enriched with TBET-enriched CD16+ and IRF1-enriched CD14+ monocytes, which were determined to have a trained and activated apparent state
    .

    In the B-cell lineage analysis, the B-cells of patients with new coronary pneumonia at various stages showed plasma cell-like differentiation characteristics of IgG class switching and antibody secretion
    .

    In T cell lineage analysis, the researchers created a new single-cell multi-omics Ti-ATAC-seq technology, which can simultaneously obtain the accessible chromatin information, TCR sequence, and cell membrane molecular expression of each T cell at the single cell level.
    Level
    .

    In-depth analysis of CD8+ T cell epigenetic profiles and single-cell TCR clones in patients recovered from new coronary pneumonia revealed that virus-induced effector CD8+ T cells played a key role in the formation of immune memory in the initial control of new coronavirus and memory CD8+ T cells
    .

    The paper Yang Pengyuan, Mark M Davis and Chen Liang are the co-corresponding authors, and You Maojun is the first author
    .

    It is worth mentioning that during the same period, Mihai G.
    Netea and Yang Li of Radboud University Nijmegen Medical Centre published a review article Immune memory in individuals with COVID-19 in response to this article
    .

    Original link: https:// Cell Biology Concurrent review article link: https:// :Eleventh reprinting instructions [Non-original articles] The copyright of this article belongs to the author of the article.
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    .

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