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    Home > Active Ingredient News > Infection > Nearly half of COVID-19 patients still have symptoms after 1 year. Professor Cao Bin’s team "The Lancet" published a large-scale study

    Nearly half of COVID-19 patients still have symptoms after 1 year. Professor Cao Bin’s team "The Lancet" published a large-scale study

    • Last Update: 2021-10-02
    • Source: Internet
    • Author: User
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    ▎The long-term impact of the WuXi AppTec content team's editing of the new coronavirus infection has been widely reported and has attracted more and more attention
    .

    Recently, "The Lancet" has published the results of a one-year follow-up of hospitalized patients with the new crown
    .

    The health assessment of more than 1,000 patients at 6 months and 12 months showed that although most of these patients’ symptoms have been significantly improved after 1 year and they have returned to normal work and life, they generally still have not fully recovered.
    About half of patients still have at least one symptom, and about 1/3 of patients still have shortness of breath
    .

    Professor Cao Bin from the China-Japan Friendship Hospital is the corresponding author of the paper, and Professor Wang Jianwei from Peking Union Medical College and Dr.
    Wang Xianguang from Wuhan Jinyintan Hospital are co-senior authors
    .

    Professor Cao Bin said: “Assessing the health outcomes of hospitalized patients with COVID-19 after one year of onset, this is the largest study to date
    .
    The
    results of the study indicate that it will take more than one year for some patients to recover.
    We should consider providing long-term support for these patients during the service
    .

    "The Lancet published an editorial in the same period, pointing out, "As the new crown pandemic continues, the need to understand and respond to the long COVID is more and more urgent
    .

    Continued fatigue Symptoms such as dyspnea, brain fog, and depression may debilitate millions of people around the world, but we don’t know much about these conditions.
    .
    .
    The prolonged new crown is one of the top challenges of modern medicine
    .

    " Screenshot source: The Lancet earlier this year.
    The research team published a paper in The Lancet and reported on the health status of more than 1,700 patients with new crowns after discharge for 6 months.
    About 3/4 of the patients still have at least one symptom.

    .

    The new study published this time further followed up 1276 of these patients for up to 12 months.
    These patients were discharged from Wuhan Jinyintan Hospital from January 7 to May 29, 2020.
    Onset of onset (calculated based on the date of the first symptom) ) After 6 months and 12 months, they underwent a detailed health assessment
    .

    The results showed that, regardless of the initial severity of the illness, many symptoms will significantly subside over time, including fatigue or muscle weakness, sleep difficulties, hair loss, smell and taste disorders
    .

    One year later, the proportion of patients with at least one symptom dropped from 68% at 6 months to 49% at 12 months
    .

    However, some patients’ long-term symptoms and lung abnormalities lasted for nearly a year, especially those who were severely ill during hospitalization
    .

    Among the long-term symptoms, fatigue or muscle weakness is the most common.
    About half of patients still have fatigue and muscle weakness at 6 months, and the proportion of patients experiencing these problems drops to one-fifth a year later
    .

    One year later, nearly one-third (30%) of patients still reported shortness of breath, slightly higher than the rate at 6 months (26%)
    .

    Compared with patients who do not require oxygen therapy during hospitalization, this condition is more common in the most severely ill patients who have been using ventilators during hospitalization (39% vs 25%)
    .

    244 patients completed lung function tests at 6 and 12 months
    .

    After one year, most patients' vital capacity and lung volume parameters were within the normal range
    .

    However, regardless of the condition at the time of hospitalization, the proportion of patients who experienced diffusion disorders (reduced oxygen flow from the lungs to the bloodstream) did not improve
    .

    The paper pointed out that the diffusion disorder can be attributed to lung epithelial injury, interstitial or pulmonary vascular abnormalities
    .

    The proportion of patients with diffusion disorder is as follows: Acute illness is grade 3, no supplemental oxygen is required during hospitalization: 21% at 6 months, 23% at 12 months; acute illness is grade 4, supplementary oxygen is required during hospitalization: 26 at 6 months %, 31% at 12 months; Acute illness level 5-6, requiring ventilation during hospitalization: 57% at 6 months and 54% at 12 months
    .

    Among the patients with abnormal lung CT at 6 months, 118 completed the re-examination at 12 months.
    The imaging results indicated that the lungs of the patients were gradually returning to normal, but the abnormal proportion was still high
    .

    Especially in the most critically ill patients (grades 5-6) during hospitalization, the proportion of abnormal lung imaging examinations is as high as 87%, and among patients with grade 3 and 4, 39% and 40%, respectively
    .

    Image source: 123RF Generally speaking, female patients have more obvious long-term effects on some symptoms
    .

    After one year, women are 1.
    4 times more likely to report fatigue or muscle weakness than men, 2 times more likely to report anxiety or depression, and 3 times more likely to have pulmonary diffusion disorders
    .

    Patients who received corticosteroid therapy during the COVID-19 hospitalization also had a 50% higher chance of fatigue or muscle weakness one year later
    .

    The research team pointed out that these patient characteristics are very important for future research follow-up
    .

    The lives and work of most patients are back on track
    .

    1252 patients reported their work before and after discharge
    .

    Because patients are generally older (median age 59 years), about half of the patients (53%) have retired before contracting the new coronavirus
    .

    Patients who had worked before the infection basically (88%) had returned to their original jobs after one year, and most (76%) had returned to their original work levels
    .

    In addition, the research team also compared these patients with a control group of people who were not infected with the new crown and were similar in age, gender, and previous physical condition
    .

    After one year, most patients’ health status is still lower than that of the general population.
    All the symptoms in the questionnaire are more common, with more pain or discomfort (29% vs 5%), and more likely to encounter mobility problems (9%).
    vs 4%)
    .

    The author pointed out that although the study failed to collect data on these patients before they became ill, the matched control population provides a meaningful reference and helps to understand the impact of the disease on the patient’s long-term quality of life
    .

    Mental health is also an important factor in considering the degree of recovery of patients
    .

    After one year, the proportion of patients with symptoms of anxiety or depression increased slightly compared with that at 6 months (26% vs 23%), and this proportion was significantly higher than that of the control population who was not infected with the new crown (5%)
    .

    “We still don’t fully understand why psychiatric symptoms are more common in patients with COVID-19 after one year than at 6 months
    .

    ” One of the authors of the paper, Dr.
    Gu Xiaoying from the China-Japan Friendship Hospital, added, “This may be due to viral infection or human immune response.
    Related biological processes may also be caused by decreased social contact, loneliness, incomplete physical recovery, or work affected by illness
    .

    " WuXi AppTec's content team mapping research team also pointed out that this study focused on patients in a hospital, so it is relevant The results may not be representative of the conditions of other diagnosis and treatment environments
    .

    The study included only a small number of patients (94/1276) who received intensive care on admission, and it is necessary to carefully interpret the outcome of the most critically ill patients
    .

    The paper finally pointed out that “continuous longitudinal follow-up is still needed to better understand the natural history and pathogenesis of the long-term health consequences of the new crown
    .

    "The Lancet" editorial article emphasized that understanding, rehabilitation, and research on the long-term consequences of the new crown are "a challenge that the entire health community must deal with
    .
    "
    "The article further pointed out that at present, most of the evidence on long-term COVID-19 is limited to small cohort studies with short-term follow-up.
    This latest study has improved by reporting the 12-month results of the "largest-scale longitudinal study cohort of adult patients with COVID-19 so far.
    " Our understanding of the nature and scope of the long-term new crown
    .
    In the
    future, “the scientific community and the medical community need to cooperate to explore the long-term pathological mechanism, assess the global and local disease burden, better identify the highest-risk population, understand how the vaccine affects the disease, and adopt Randomized controlled trials find effective treatments
    .

    …The health system needs to prepare professionals to achieve individualized, patient-oriented (rehabilitation) goals
    .

    "
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