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    Home > Active Ingredient News > Infection > NEJM: A single high-dose liposomal regimen of amphotericin B for HIV-associated cryptococcal meningitis

    NEJM: A single high-dose liposomal regimen of amphotericin B for HIV-associated cryptococcal meningitis

    • Last Update: 2022-04-19
    • Source: Internet
    • Author: User
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    Cryptococcal meningitis is the most common cause of meningitis in adults in areas of high HIV burden and the second leading cause of HIV-related deaths worldwide, with most deaths occurring in sub-Saharan Africa


    We investigated the efficacy of a single high-dose regimen of liposomal amphotericin B in the treatment of HIV cryptococcal meningitis



    Non-inferiority endpoint for patient mortality between groups

    Between- group patient mortality met non-inferiority endpoint

    CONCLUSIONS: The single-dose liposomal amphotericin B-flucytosine-fluconazole combination regimen is as effective as the current WHO-recommended regimen in the treatment of HIV-associated cryptococcal meningitis, with a lower adverse event rate


    The single-dose liposomal amphotericin B-flucytosine-fluconazole combination regimen has the same efficacy in the treatment of HIV-associated cryptococcal meningitis as the current WHO-recommended regimen with a lower adverse event rate
    .
    The single-dose liposomal amphotericin B-flucytosine-fluconazole combination regimen has the same efficacy in the treatment of HIV-associated cryptococcal meningitis as the current WHO-recommended regimen with a lower adverse event rate
    .

    Original Source:
    Single-Dose Liposomal Amphotericin B Treatment for Cryptococcal Meningitis.


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