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    Home > Active Ingredient News > Study of Nervous System > NEJM: Analysis of the efficacy of sodium benzoate-taurine glycol in the treatment of amyotrophic lateral sclerosis.

    NEJM: Analysis of the efficacy of sodium benzoate-taurine glycol in the treatment of amyotrophic lateral sclerosis.

    • Last Update: 2020-09-25
    • Source: Internet
    • Author: User
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    In experimental models, sodium benzoate and taurine glycol have been found to reduce neuron death.
    the efficacy and safety of these two compounds in patients with amyotrophic lateral sclerosis (ALS).
    , researchers recruited alS participants who had been diagnosed with symptoms in the past 18 months in a multi-center, randomized, double-blind trial published in the top medical journal NEJM.
    participants were randomly assigned sodium benzoate-taurine glycol (3 g sodium phenyrate and 1 g taurine glycol, once a day for 3 consecutive weeks, and then twice a day) or placebo therapy at a 2:1 scale.
    The main outcome of this study was the rate of decline of the total score of the revised amyotrophic lateral sclerosis function scale (ALSFRS-R; the higher the score indicates better function), the secondary outcome was isometremic force, plasma phosphate axon surrosis H sub-base level drop, lung capacity, death, tracheotomy or permanent air conditioning;
    the study screened 177 ALS patients and randomly assigned 137 people to receive sodium benzoate-taurine glycol (89 participants) or placebo (48 participants).
    In the improved intentional therapy analysis, the average change rate of alSFRS-R for active drugs was -1.24 points per month, and for placebos it was -1.66 points per month (difference was 0.42 points per month; 95 percent confidence range was 0.03 to 0.81; P was 0.03).
    two groups had no significant difference in secondary outcomes.
    reactions to active drugs are mainly concentrated in the gastrointestinal tract.
    alS patients treated with sodium benzoate-taurine glycol showed slower functional decline than placebos, according to alSFRS-R.
    two groups had no significant difference in secondary outcomes.
    necessary for larger and larger trials to assess the efficacy and safety of sodium benzoate-taurine glycol in ALS patients.
    .
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