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    Home > Active Ingredient News > Antitumor Therapy > NEJM: Cardiovascular disease and cancer risk in tofacitinib-treated rheumatoid arthritis patients

    NEJM: Cardiovascular disease and cancer risk in tofacitinib-treated rheumatoid arthritis patients

    • Last Update: 2022-02-20
    • Source: Internet
    • Author: User
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    Compared with tumor necrosis factor (TNF) inhibitors, tofacitinib increases blood lipid levels and cancer risk


    rheumatoid arthritis cardiovascular

    In a study published today in the top medical journal NEJM, researchers conducted a randomized, open-label, non-inferiority, authorized, safety endpoint trial


    The study's co-primary endpoints were adjudicated MACE and cancer, excluding non-melanoma skin cancer


    A total of 1455 patients received tofacitinib 5 mg twice daily, 1456 patients received tofacitinib 10 mg twice daily, and 1451 patients received TNF inhibitor therapy


    Infect

    CONCLUSIONS: Combining doses of tofacitinib and a TNF inhibitor was compared in a population at cardiovascular risk, with a higher risk of MACE and cancer in the tofacitinib group, and some adverse events more frequently with tofacitinib


    Combining doses of tofacitinib with a TNF inhibitor was compared in a population at cardiovascular risk, with a higher risk of MACE and cancer in the tofacitinib group and some adverse events more frequently with tofacitinib


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