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    Home > Active Ingredient News > Infection > NEJM: Combination of vaccines and drug prevention significantly reduces the risk of seasonal malaria in the Sahel

    NEJM: Combination of vaccines and drug prevention significantly reduces the risk of seasonal malaria in the Sahel

    • Last Update: 2021-09-10
    • Source: Internet
    • Author: User
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    In the Sahel region between the Sahara desert and grassland areas in central Sudan in northern Africa, seasonal malaria remains a serious infectious disease, carried sulfadoxine per month transmission season - pyrimethamine - amodiaquine chemical prophylaxis treatment Although the effect is significant, the local malaria burden is still very heavy


    Prevention Recently, researchers have investigated the role of seasonal malaria chemopreventive treatment combined vaccines in controlling the spread of malaria in the area


    This study is a non-inferiority randomized controlled study to evaluate the effects of seasonal RTS and S/AS01E vaccination in the prevention of uncomplicated malaria.


    6861 large 5-17 months children participated in the study, in which 2287 children received only sulfadoxine - pyrimethamine - amodiaquine chemopreventive treatment (chemoprophylaxis group), 2288 children received only RTS, S / AS01E Vaccination (vaccine group), 2286 children received vaccine plus drug prophylaxis (combined treatment group), followed up for 3 years


    childEpilepsy and simple compared to drug prevention, drug vaccine plus joint program of clinical malaria preventive effect of 62.


    Malaria prevention effects of drugs, vaccines and joint programs

    Drugs, vaccines, and the malaria prevention effects of the joint program Drugs, vaccines, and the malaria prevention effect of the joint program

    Studies believe that the RTS, S/AS01E vaccine is as effective as a chemical drug prevention program in preventing uncomplicated malaria


    The effect of RTS, S/AS01E vaccine in preventing uncomplicated malaria is equivalent to that of chemoprevention programs


    Original source:

    Daniel Chandramohan et al.


    Seasonal Malaria Vaccination with or without Seasonal Malaria Chemoprevention.


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