NEJM data on nearly 1.7 million people: HPV vaccine reduces cervical cancer risk by up to 88%

The HPV vaccine's effectiveness in preventing HPV infection and pre-cervical lesions has been supported by large-scale population study data in several countries.
, severe pre-cancer lesions are considered the best predictors of invasive cancer risk.
, and further, have we accumulated enough definitive evidence of the preventive effects of hpV vaccines on the development of severe cervical cancer? A large study published recently in the New England Journal of Medicine (NEJM) presents a powerful and important supporting evidence.
11-year follow-up of the Swedish population showed that women who had been vaccinated against HPV had a significantly lower risk of cervical cancer, and that this positive effect was most pronounced among women who were vaccinated at a young age.
photo source: New England Journal of Medicine From the Karolinska Institute in Sweden.
Sweden introduced a national HPV vaccination programme for girls aged 10-18 in May 2007 and began supplementary vaccinations for girls and adult women in 2012.
in Sweden, women are almost always vaccinated against four-priced HPV vaccines (covering HPV 6, HPV 11, HPV 16 and HPV 18).
researchers tracked about 1.673 million women between the ages of 10 and 30 between 2006 and 2017 and screened and assessed them for cervical cancer until they reached the age of 31.
11 years, more than half a million women have been vaccinated against HPV, and most have been vaccinated by the age of 17.
19 and 538 people were diagnosed with cervical cancer, respectively, with a cumulative incidence equivalent to 47 per 100,000 women and 94 per 100,000 women, respectively.
, the risk of cervical cancer in women who were vaccinated against HPV was significantly reduced by 49% after adjusting for age.
, the risk of cervical cancer in women vaccinated against HPV was significantly reduced by 63% after continuing to adjust factors such as residence, education level, family situation and related medical history! Further analysis of the age of vaccination found that among women who were vaccinated against HPV before the age of 17, the risk of cervical cancer was significantly reduced by 88%! In women aged 17-30 who were indirectly vaccinated against HPV, the risk of cervical cancer was also halved and reduced by 53%.
The difference between different vaccination ages and protective effects, " explains Dr. Pär Sparén, a professor at the Karolinska School of Medicine, "this may be because young girls are less likely to be infected with HPV, and the HPV vaccine has no therapeutic effect on past infections."
overall, the team believes data from women aged 10-30 in Sweden show that getting a four-pyrethroid HPV vaccine can significantly reduce the risk of indulging cervical cancer, especially in women who are vaccinated early.
"This is the first time that HPV vaccination has been shown at the population level not only to prevent cellular changes that may be an early sign of cervical cancer, but also to actually prevent immersive cervical cancer," said Dr. Jiayao Lei of the Karolinska School of Medicine and lead author of the study.
we've wanted to confirm this for a long time, and now it's finally proven in a large-scale study.
" References, Jiayao Lei, et al., (2020). HPV Inga and Risk of Invasive Cervical Cancer. N Engl J Med, DOI: 10.1056/NEJMoa1917338. Retrieved October 9, 2020, from.