NEJM: Humoral immune response weakened within 6 months after vaccination of Covid-19 vaccine BNT162b2

Despite the high vaccine coverage and effectiveness, the incidence of symptomatic infections with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been increasing in Israel
.

Recently, a research article was published in the top medical journal NEJM.
Researchers conducted a 6-month longitudinal prospective study involving medical workers who had been vaccinated.
They received monthly anti-spike IgG and neutralization.
Antibody detection
.

The study included 4868 participants, of which 3808 were included in the linear mixed model analysis
.

6 months after the second dose, men’s neutralizing antibody titers were significantly lower than women’s (mean ratio 0.
64; 95% confidence interval [CI] 0.
55 to 0.
75), 65 years old or 18 to 45 years old In the population (mean ratio 0.
58; 95% CI 0.
48 to 0.
70), and in immunosuppressed participants lower than those without immunosuppression (mean ratio 0.
30; 95% CI 0.
20 to 0.
46)
.

It can be seen that 6 months after vaccination of the second dose of BNT162b2 vaccine, the humoral immune response was significantly reduced, especially in men, people 65 years of age or older, and immunosuppressed people
.

Original source:
 
Bertram Pitt,et al.