NEJM: Left atrial appendage occlusion in patients with atrial fibrillation can effectively prevent stroke

Brain stroke is the leading cause of death of Chinese residents , due to atrial fibrillation, cardiogenic stroke as one of the high incidence and type a great harm, serious harm to national health, increased social burden.

Atrial fibrillation (atrial fibrillation) is one of the most common types of medsci.

The early stage within 14 days after the onset of cardiogenic stroke caused by atrial fibrillation is not only a high-risk period for recurrence of stroke, but also a high-risk period for cerebral hemorrhage.

Researchers conducted a multi-center randomized trial involving atrial fibrillation who planned to undergo cardiac surgery for other reasons and a CHA2DS2-VASc score of at least 2 points (the score ranges from 0 to 9, the higher the score, the greater the risk of stroke) Participants.

Surgery diagram

The main analysis population included 2379 participants in the occlusion group and 2391 participants in the non-occlusion group, with an average age of 71 years and an average CHA2DS2-VASc score of 4.

114 participants (4.

Cumulative risk of stroke in the non-occlusion group (red) and the occlusion group (blue)

In summary, patients with atrial fibrillation undergoing left atrial appendage occlusion can reduce the risk of ischemic stroke or systemic embolism.

references:

Richard P.