echemi logo
Product
  • Product
  • Supplier
  • Inquiry
    Home > Active Ingredient News > Study of Nervous System > NEJM: Liu Jianmin's team from Naval Military Medical University revealed that patients with acute anterior circulation large vessel occlusive ischemic stroke within 4.5 hours can be directly removed

    NEJM: Liu Jianmin's team from Naval Military Medical University revealed that patients with acute anterior circulation large vessel occlusive ischemic stroke within 4.5 hours can be directly removed

    • Last Update: 2022-01-08
    • Source: Internet
    • Author: User
    Search more information of high quality chemicals, good prices and reliable suppliers, visit www.echemi.com

    Stroke is the leading cause of death in our country
    .


    According to reports, there are more than 3.


    On May 21, 2020, the Liu Jianmin team of Naval Military Medical University published a research paper entitled "Endovascular Thrombectomy with or without Intravenous Alteplase in Acute Stroke" online in the top international medical journal NEJM.
    This research is a prospective, multi-center, randomized research paper.
    A controlled study, covering 41 academic tertiary hospitals across the country, screened a total of 1586 patients with anterior circulation acute large vessel occlusive ischemic stroke with an onset of less than 4.
    5 hours.
    Finally, 656 cases were included in the study and randomized at a ratio of 1:1 Divided into the direct thrombectomy group (simple intravascular thrombectomy, 327 cases) and the combined treatment group (pre-thrombectomy alteplase intravenous thrombolysis, alteplase administered at a dose of 0.
    9 mg/kg, 329 cases )
    .

    The study found that intravascular thrombectomy alone was not inferior to intravenous alteplase and intravascular thrombectomy combined therapy (adjusted common odds ratio, 1.
    07; 95% confidence interval, 0.
    81 to 1.
    40; non-inferiority P=0.
    04 )
    .


    However, the rate of successful reperfusion before thrombectomy (2.


    In conclusion, for patients with acute anterior circulation large vessel occlusive ischemic stroke within 4.
    5 hours of onset, the effect of simple intravascular thrombus removal is not inferior to alteplase intravenous thrombolysis combined with intravascular removal in terms of improving functional outcomes.
    Embolization
    .

     

    Faced with the worldwide problem of "stroke", in recent years, the standard treatment method of thrombolysis followed by thrombus removal has been generally recommended
    .


    However, due to limitations such as the division of inherent disciplines, poor regional referrals, and lack of sufficient understanding of patients, the combined therapy of intravenous thrombolysis and arterial thrombolysis is not ideal in the actual operation process, which greatly affects the treatment effect


    Alteplase may increase the early reperfusion of the ischemic area and dissolve the residual distal thrombus after intravascular thrombus removal
    .


    However, for the large thrombus located at the proximal end, intravenous alteplase has a limited dissolution effect.


    The study performed direct intra-arterial thrombectomy to effectively revascularize patients with acute ischemic stroke with large vessel occlusion in tertiary hospitals in China: a multicenter randomized clinical trial (DIRECT-MT) to identify individual vessels Is internal thrombectomy not inferior to intravenous alteplase followed by intravascular thrombectomy (acute ischemic stroke patients with anterior circulation large vessel occlusion)
    ?

    The study is a prospective, multi-center, randomized controlled study covering 41 academic tertiary hospitals across the country.


    A total of 1586 patients with anterior circulation acute macrovascular occlusive ischemic stroke with an onset of less than 4.


    Of the 1586 patients screened, 656 were included, of which 327 patients were assigned to the thrombus removal group alone and 329 were assigned to the combined treatment group
    .


    In terms of the main outcome, intravascular thrombectomy alone was not inferior to intravenous alteplase and intravascular thrombectomy combined therapy (adjusted common odds ratio, 1.


    In conclusion, for patients with acute anterior circulation large vessel occlusive ischemic stroke within 4.


    Reference News:

    https:// id="js_a11y_like_btn_tips" class="weui-hidden_abs" aria-hidden="true">

    Leave a message here
    This article is an English version of an article which is originally in the Chinese language on echemi.com and is provided for information purposes only. This website makes no representation or warranty of any kind, either expressed or implied, as to the accuracy, completeness ownership or reliability of the article or any translations thereof. If you have any concerns or complaints relating to the article, please send an email, providing a detailed description of the concern or complaint, to service@echemi.com. A staff member will contact you within 5 working days. Once verified, infringing content will be removed immediately.

    Contact Us

    The source of this page with content of products and services is from Internet, which doesn't represent ECHEMI's opinion. If you have any queries, please write to service@echemi.com. It will be replied within 5 days.

    Moreover, if you find any instances of plagiarism from the page, please send email to service@echemi.com with relevant evidence.