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NEJM: MRI targeting vs standard prostate biopsy for prostate cancer screening in the general population

 Last Update: 2021-09-11
 Source: Internet
 Author: User

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Systematic prostate cancer screening , that is, ultrasound-guided transrectal biopsy of the prostate for people with elevated PSA levels after the prostate-specific antigen (PSA) test is essential to reduce the mortality of prostate cancer.

Screening Recently, researchers have investigated the application prospects of targeted biopsy strategies based on magnetic resonance imaging (MRI) in population-based prostate cancer screening

This study is a population-based non-inferiority trial for prostate cancer screening, in which ordinary men aged 50-74 are invited to participate by email.

12,750 participants, 1532 of whom had a PSA level of 3ng/ml or higher, were randomly assigned to undergo biopsy, of which 603 were assigned to the standard biopsy group and 929 received MRI-guided biopsy

In the intention-to-treat analysis, 192 patients (21%) in the MRI-guided biopsy group had a Gleason score ≥7 and were diagnosed as clinically significant malignant cancer, compared with 106 patients in the standard biopsy group (18%, a difference of 3%)

Studies have concluded that among suspected prostate cancer patients with elevated PSA levels, prostate biopsy guided by MRI has a high detection rate of malignant diseases, while the rate of non-essential biopsy is reduced

In patients with suspected prostate cancer with elevated PSA levels, the detection rate of malignant diseases in prostate biopsy guided by MRI is high, while the rate of non-essential biopsy is reduced

Original source:

Martin Eklund et al.

MRI-Targeted or Standard Biopsy in Prostate Cancer Screening.

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