NEJM: Severe Toxicity Report of Yvonne - Case Report.

Yvonne was discovered in the early 1970s and approved in 1981 as an anti-parasitic drug for animals.
the drug is a large ring ester extracted from Yvonne B1, a compound produced by streptomycin.
is considered the drug of choice for many parasitic infections, has a wide range of activities for mites, insects and parasites, and is very safe.
high safety of iverin is mainly due to its inability to be combined in the blood-brain barrier by the multi-resistance protein ABCB1, also known as P-glycoprotein.
in some non-synonymable mutant dogs of ABCB1 and abcb1-knocking mice, however, can lead to severe neurological disorders and even death.
's not immediately speaking to ABCB1.
this case reported that a 13-year-old boy was taken to the pediatric intensive care unit with impaired consciousness.
he was given oral yvythylobacter (0.23 mg per kg body weight) 2 hours and 30 minutes before his consciousness was impaired to prevent hemorrhoid infection.
his condition worsened six hours after receiving ivemiculose treatment and developed persistent neurological signs, including coma, comorbid disorders, cone signs, double vision, and abdominal pain and vomiting.
the child's Glasgow score fluctuated during the 48-hour monitoring period, but the results of the supplementary examination were normal.
fully recovered after 48 hours.
suspected that the child was poisoned with iverin, abcB1 sequencing showed that the child's genome became a compound heterogeneous hybrid, including two non-synonymic mutations: NC_000007.13 (NM_000927.4): c.2380C-T and NC_000007.13 (NM_000927.4): c.3053_3056delITTGA.
genetic analysis of the patient's family to confirm allegene separation.
loss of ABCB1 activity can lead to failure of brain protection, which can lead to significant exposure of the central nervous system to iverin and the toxic effects observed in this study.
Serius Ivermectin Toxicity and Human ABCB1 Nonsense Mutations, n engl j med 383; 8 nejm.orgAugust 20, 2020.Source:MedSci Originals !--Scity-Content Presentation Ends -- !-- To Determine If Login Ends.