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    Home > Active Ingredient News > Infection > NEJM: Short-term treatment of non-severe tuberculosis in children in Africa and India

    NEJM: Short-term treatment of non-severe tuberculosis in children in Africa and India

    • Last Update: 2022-04-19
    • Source: Internet
    • Author: User
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    Two-thirds of children with TB have non-severe disease that can be treated with a shorter regimen than the current six-month regimen
    .

    child

    In a recent study published in the top medical journal NEJM, researchers conducted an open-label, shorter-duration, non-inferiority trial in Uganda, Zambia, South Africa, and India involving non-serious, symptomatic, potentially adverse effects.
    Drug-susceptible children with smear-negative tuberculosis
    .


    Children under the age of 16 were randomly assigned to receive either 4 months (16 weeks) or 6 months (24 weeks) of standard first-line antituberculosis therapy using a fixed pediatric proportional-dose combination, as recommended by the World Health Organization


    The primary efficacy outcome of the study was adverse status at 72 weeks (treatment failure [extending, changing or restarting treatment or TB relapse], loss to follow-up or death during treatment), excluding participants who did not complete 4 months of treatment (modified intent-to-treat population)
    .


    The researchers used a noninferiority margin of 6 percentage points


    From July 2016 to July 2018, a total of 1204 children in the study were randomized (602 in each group)
    .


    The median age of participants was 3.


    immune infection

    Thus, for children with drug-sensitive, non-severe, smear-negative tuberculosis, 4-month anti-TB treatment was not inferior to 6-month treatment
    .

    For children with drug-sensitive, non-severe, smear-negative TB, 4 months of anti-TB treatment was noninferior to 6 months of treatment
    .


    Original source:
     
    Anna Turkova, et al.


    Shorter Treatment for Nonsevere Tuberculosis in African and Indian Children .
    NEJM.



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