NEJM: Study of genetic characteristics in patients with respiratory failure of new coronary pneumonia.

Patients infected with Coronary Virus Type 2 (SARS-CoV-2) with Severe Acute Respiratory Syndrome (SARS-CoV-2) have significant differences in disease behavior, and researchers recently conducted genome-wide association analysis to identify potential genetic factors associated with the severity of Covid-19 disease.
researchers conducted a genome-wide association study involving 1980 patients with Covid-19 with respiratory failure at seven hospitals in Italy and Spain where SARS-CoV-2 is endemic in Europe.
outlier, the final analysis included 835 patients from Italy and 1,255 control participants, 775 patients from Spain and 950 control participants.
8582968 single nucleotide polymorphisms were analyzed, and two case control groups were analyzed.
compared to the control group, the researchers detected cross-replication associations at rs11385942 at 3p21.31 bits and cross-replication associations at rs657152 at 9q34.2-bit points, with significant differences at genome-wide levels (advantage ratios of 1.77 and 1.32, respectively).
at 3p21.31 bits, the associated signal spans the SLC6A20, LZTFL1, CCR9, FYCO1, CXCR6, and XCR1 genes.
signal of the 9q34.2 bit is consistent with the ABO blood type bit.
of blood type specificity showed that the risk of infection was higher in people with blood type A than in other blood types (risk ratio: 1.45), while O blood type had a protective effect (risk ratio: 0.65).
study found that the 3p21.31 gene cluster was a genetic susceptible position in patients with Covid-19 respiratory failure, and confirmed the relationship between the ABO blood type system and susceptible to neocoopon pneumonia.
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