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NEJM: The effect of anti-B cell maturation antigen CAR-T cell therapy bb2121 in the treatment of multiple myeloma

 Last Update: 2021-05-20
 Source: Internet
 Author: User

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bb2121 is a chimeric antigen receptor (CAR) T cell therapy against B cell maturation antigen (BCMA).

The study included patients with relapsed or refractory multiple myeloma.

⁶⁶⁶⁶⁶⁶Immunity

The study reported the results of 33 consecutive patients who received the earliest input of bb2121.

During the trial, a total of 25 patients (76%) developed cytokine release syndrome, of which 23 cases (70%) were grade 1 or 2, and 2 cases (6%) were grade 3.

The median progression-free survival was 11.

In summary, the study reported the preliminary toxicity characteristics of patients with relapsed or refractory multiple myeloma after receiving cellular immunotherapy targeting BCMA, and the study confirmed the anti-tumor activity of bb2121.

Original source:

Noopur Raje, et al.

ncbi.
nlm.
nih.
gov/31042825/" target="_blank" rel="noopener">Anti-BCMA CAR T-Cell Therapy bb2121 in Relapsed or Refractory Multiple Myeloma

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