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Dengue fever is an acute viral syndrome transmitted by mosquitoes caused by any of the four serotypes of Dengue virus (DENV)
.
In 2019, the World Health Organization listed dengue fever as one of the top ten global health threats
Approximately 50 million to 100 million symptomatic cases appear worldwide every year
Management There are currently few randomized trials of Aegypti mosquito control methods, and none of the trials use virological confirmation of dengue fever (VCD) as a judging endpoint
Wolbachia pipientis-a common, maternally inherited, obligate intracellular bacteria-can infect a variety of insects, but it does not naturally infect Aedes aegypti
.
Stable transfection of Aedes aegypti with certain Wolbachia strains gives them resistance to DENV and other arboviruses
Infected Aedes aegypti and stability in some of the Wolbachia strains transfected gives them to DENV infection and other arboviruses spread of resistance
They conducted a cluster randomized trial in Yogyakarta, Indonesia, involving the release of wMel-infected Aegypti mosquitoes to control dengue fever
.
We randomly assigned 12 geographic clusters to receive the deployment of wMel-infected Aedes aegypti (intervention cluster) and 12 clusters that did not receive deployment (control cluster)
In this experiment, after successfully infiltrating wMel into the intervention cluster, a total of 8144 participants were recruited;3721 people lived in the intervention cluster, and 4423 people lived in the control cluster
.
In the intention-to-treat analysis, 67 (2.
Experimental results show that introducing the wMel gene into the Aedes aegypti population can effectively reduce the incidence of symptomatic dengue fever and reduce the number of participants who are hospitalized due to dengue fever
.
.
Original link: https:// href="https://" target="_blank" rel="noopener">https:// of Wolbachia-Infected Mosquito Deployments for the Control of Dengue
Adi Utarini, MD, Ph.
D.
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