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The relationship between the new coronavirus and the brain has always been curious.
as the highest "command" of the human body.
there is ample evidence that COVID-19 is neuro-invasive.
early first-hand data from Wuhan showed that 36.4% of COVID-19 patients had neurological symptoms, such as insomnia, headache, stroke and even consciousness disorders, during hospitalization.
, however, it remains uncertain whether the new coronavirus is directly targeting the central nervous system (CNS) or whether neurological symptoms reflect a systemic response.
Previous studies from leading journals such as The New England Journal of Medicine, Nature and Neurology have used different experimental methods to test the effects of the new coronavirus on the nervous system in different ways, and have shown that COVID-19 has long-term effects on brain structure and function.
addition, recently, researchers at Temple University's Lewis Katz School of Medicine and others reported in a new academic journal, Neurobiological Diseases, that the new coronavirus prickly protein affects endodertic cells in the blood vessels of the brain.
the latter is part of the blood-brain barrier.
the study, the prickly protein allows the endoder cells to react in an inflammatory way.
suggests that neo-coronavirus protrusion proteins can cause the blood-brain barrier in key areas of the brain to lose stability, while changes in blood-brain barrier function significantly increase the likelihood that the new coronavirus will invade the nerves, providing an explanation for neurological symptoms in new coronary patients.
so how does the new coronavirus damage the blood vessels in the brain? Is this damage related to infection of brain tissue? To that end, a team led by scientists at the National Institutes of Health (NIH) conducted research on the issue.
results are published in the latest NEJM journal.
In the study, researchers isolated brain samples from 19 patients who died from COVID-19, using an advanced MRI technique that scans samples, mainly olfactory balls and brain trachea , four to 10 times more sensitive than conventional MRIs.
results showed that there were some unusual bright spots (suggesting inflammation) and dark spots (hinting bleeding) in both areas.
, the researchers analyzed the area using a microscope.
results showed that blood vessels were generally thinner in the areas where inflammation was suggested, i.e. in the bright spots mentioned above, and sometimes leakage caused blood proteins to be released into the brain, causing an immune response.
the above-mentioned dark spots, although there is leakage, but there is no immune response.
researchers say the phenomenon is unexpected.
because initially they thought the damage to brain tissue was due to lack of oxygen, but the pathological phenomena observed often occurred in strokes or neuro-inflammatory disorders.
other researchers have noted that the patient's brain may be prone to microvascular damage, perhaps because of the body's immune response.
interestingly, none of the researchers detected the presence of the new coronavirus in the above samples.
also suggests that the virus does not need to infect brain tissue and may be able to affect blood vessels in the brain and cause damage.
, the study sheds new light on the breadth of brain damage caused by the new coronary disease and will help future doctors assess patients' symptoms more fully.
is a reminder that people with pneumonia should be given sustained attention to changes in their nervous system.
: Lee MH, et al. Microvascular Injury in the Brains of Patients with Covid-19. N Engl J Med. 2020 Dec 30. doi: 10.1056/NEJMc2033369.MedSci Original Source: MedSci Original Copyright Notice: All text, images and audio and video materials on this website that state "Source: Mets Medicine" or "Source: MedSci Originals" are owned by Mets Medicine and are not authorized to be reproduced by any media, website or individual.
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