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    Home > Active Ingredient News > Infection > NEJM: Three consecutive rounds of large-scale azithromycin administration to prevent and control yaws!

    NEJM: Three consecutive rounds of large-scale azithromycin administration to prevent and control yaws!

    • Last Update: 2022-01-22
    • Source: Internet
    • Author: User
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    Yaws disease, also known as tropical berry sore, is a chronic contact infectious disease caused by yaws, mainly in some tropical rural areas, mostly in children and adolescents
    .


    There have been occasional sporadic cases in Guangdong, Fujian, Guangxi, Taiwan and other places in China


    child

    Treponema pallidum, also known as Treponema pallidum, is similar in shape to Treponema pallidum, with a body length of 10-13 μm, a tight helix, active movement, no growth in vitro, and can survive for several days in a special medium without proliferation
    .


    It can keep virulence for many years in the low temperature of dry ice at ~70℃


    The New England recently published the results of an open-label, cluster-randomized, community-based clinical trial
    .


    In the trial, researchers randomly divided 38 wards into two groups (19 each), the control group received one round of azithromycin group administration, followed by two rounds of targeted therapy for active cases; the experimental group received three rounds of azithromycin group Dosing


    Incidence of active cases of yaws in control and experimental groups

    The control and experimental groups included 30,438 and 26,238 subjects, respectively
    .


    The control group was injected with 24,848 doses of azithromycin, and the experimental group was injected with 59,852 doses of azithromycin


    At 18 months, the incidence of active cases of yaws in the control group decreased from 0.


    At 18 months of infection, the incidence of latent yaws was 6.


    The reduction in community prevalence of yaws after three rounds of azithromycin large-scale administration at 6-month intervals was greater than that of two rounds of targeted therapy followed by one round of azithromycin large-scale administration and three rounds of azithromycin at 6-month intervals.


    Original source:

    John Lucy N,Beiras Camila G,Houinei Wendy et al.


    Trial of Three Rounds of Mass Azithromycin Administration for Yaws Eradication Leave a Comment here
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