Nerve synaptic plasticity long-term enhanced synaptic post-molecular mechanism.

The central nervous system is one of the most complex and rigorous organs of vertebrate regulation, controlling basic neural activities such as sensory perception, emotional regulation and body maintenance, as well as advanced neural activities such as thinking, cognition and consciousness. One of the most important characteristics of the
brain is the ability to store a large amount of information, that is, learning and memory ability, and in patients with neuropsychiatric disorders such as Alzheimer's disease, abnormal learning and memory ability are one of the most important clinical characterizations. The neural synapses and mediated information transmission of
neurons are a basic and unique existence of the nervous system, and also the basis for neural networks to play physiological functions, and their activity abnormality is one of the important causes of neurological diseases.
neuroscience studies have shown that the material basis for learning memory is a change in the intensity of synaptic associations, leading to the theory of synaptic plasticity, in which the intensity of synaptic contacts between neurons changes with changes in neuronal activity.
long-range enhancement (long-term, LTP) is one of the important manifestations of synaptic plasticity, and is the most important molecular cell model for the study of learning memory.
current studies on LTP focus on the transport mechanism of synaptic excitatory AMPA receptors, and the molecular regulation mechanism after synapses is not clear.
recently, the Kunming Institute of Zoology of the Chinese Academy of Sciences, in cooperation with roger Nicoll Laboratory at the University of California, San Francisco, usa, to build gluA1-g-8 fusion AMPA receptor ampA receptor and replace the endogenous AMPA receptor by intrauterine electroelectric transfer, in collaboration with the interaction of glutamate receptor complex and synaptic PDZ stent protein in the function and mechanism of LT.
combined with hippocampus brain tablets and neuroelectrophysiology and other means, the study found that the synaptic transport of the exogenous AMPA receptor was regulated only by the fusion of the auxiliary TARP g-8, while the junction point in the AMPA/TARP receptor complex with the synaptic stent protein PDZ domain was necessary for the receptor-mediated synaptic transfer and LTP expression. further studies
found that the receptor complex formed by another family member of the glutamate receptor and its secondary Neto protein, its synaptic transport and LTP expression, also needed to interact with the synaptic stent protein PDZ domain.
results show that the synaptic mechanism of LTP expression is conservative and regulated by a common mechanism, regardless of the type of glutamate receptor, and that the post-synaptic PDZ stent protein is the main functional target in the LTP process, while the synaptic transport of glutamate receptors may be a passive collaborative process.
this study reveals the synaptic molecular mechanism of long-term enhancement of synaptic plasticity, which provides an important theoretical basis for further elucidates the molecular mechanism of learning memory and the pathogenesis of related neuropsychiatric disorders.
related research in the Journal of the National Academy of Sciences, based on the study of LTP-requires postsynaptic PDZ-domain interactions with glutamate-ball/auxiliary protein complexes.
, Sheng Neng, a researcher at the Kunming Institute of Zoology, is the first author of the paper and co-author edited by Roger Nicoll, a professor at the University of California, San Francisco.
the research was funded by the National Natural Science Foundation of China, the Chinese Academy of Sciences strategic leading science and technology special (evolutionary analysis and regulation of animal complexity), the Chinese Academy of Sciences took the lead in the action of the "100-person plan".
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