Neural Regen Res: Hippocampal structure and functional connectivity are associated with cognitive function and disability in relapsing-remitting multiple sclerosis

Multiple sclerosis is associated with changes in brain structure and function that lead to cognitive impairments in several areas, including attention, memory, and information processing speed
.

The hippocampus, an important structure in the brain involved in memory, undergoes microstructural changes in the early stages of multiple sclerosis

The team from the Sino-Japanese Friendship Hospital of Jilin University published a research article in the European Journal of Nuclear Medicine and Molecular Imaging, analyzing the function and structure of the hippocampus in patients with relapsing-remitting multiple sclerosis, and exploring the functional connection between the hippocampus and the whole brain, and the local brain function.
Correlation of changes in microstructure and resting-state cognitive function
.

This study retrospectively analyzed data from 20 patients with relapsing-remitting multiple sclerosis admitted to the Department of Neurology, Sino-Japanese Friendship Hospital, Jilin University, China, from April 2015 to November 2019
.

16 healthy volunteers were recruited as healthy control group

Compared with healthy controls, patients with relapsing-remitting multiple sclerosis had lower Montreal cognitive assessment scores, and both global and local functional connectivity in the bilateral hippocampus were both enhanced and weakened
.

Whole-brain FC analysis of bilateral hippocampus in patients with relapsing-remitting multiple sclerosis and healthy controls

Whole-brain FC analysis of bilateral hippocampus in patients with relapsing-remitting multiple sclerosis and healthy controls

Hippocampal diffusion tensor imaging data showed that compared with healthy controls, patients with relapsing-remitting multiple sclerosis had lower hippocampal anisotropy fraction values ​​and higher mean diffusivity values, suggesting structural abnormalities in the hippocampus
.

Correlation of hippocampal FC or MD values ​​with clinical scores

Correlation of hippocampal FC or MD values ​​with clinical scores

The left hippocampal whole-brain functional connectivity was negatively correlated with the Montreal Cognitive Assessment score (r=-0.
698, P = 0.
025), and the right hippocampal whole-brain functional connectivity was negatively correlated with the Extended Disability Status Scale score (r=-0.
649, P = 0.
042)
.

MD values ​​in the left hippocampus were negatively correlated with Montreal Cognitive Assessment scores (r = -0.

Left hippocampal-wide-brain functional connectivity was negatively correlated with Montreal Cognitive Assessment scores Right-side hippocampal-wide-brain functional connectivity was negatively correlated with Extended Disability Status Scale scores

The presence of functional connectivity and structural abnormalities in the hippocampus of patients with relapsing-remitting multiple sclerosis correlates with the degree of cognitive function and disability

The presence of functional connectivity and structural abnormalities in the hippocampus of patients with relapsing-remitting multiple sclerosis correlates with the degree of cognitive function and the degree of disability in the hippocampus of patients with relapsing-remitting multiple sclerosis related to disability

original source

Correlations between hippocampal functional connectivity, structural changes, and clinical data in patients with relapsing-remitting multiple sclerosis: a case-control study using multimodal magnetic resonance imaging.

Correlations between hippocampal functional connectivity, structural changes, and clinical data in patients with relapsing-remitting multiple sclerosis: a case-control study using multimodal magnetic resonance imaging.
Neural Regen Res .
2022;17(5):1115-1124.
doi:10.
4103 /1673-5374.
324855 Correlations between hippocampal functional connectivity, structural changes, and clinical data in patients with relapsing-remitting multiple sclerosis: a case-control study using multimodal magnetic resonance imaging.
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