Neural Regen Res: Patients with inflammatory bowel disease are at high risk of Parkinson's disease

Parkinson's disease (PD) is the most common neurodegenerative movement disorder.

Parkinson's disease (PD) is the most common neurodegenerative movement disorder.

More and more evidences show that inflammatory bowel disease (IBD) and Parkinson's disease (PD) have similar pathological mechanisms and closely related risk factors for disease

Ren-Shi Xu et al.

They searched the PubMed, Embase, and Cochrane databases, and searched for observational studies on IBD and PD published from the beginning to October 2019

They searched the PubMed, Embase, and Cochrane databases, and searched for observational studies on IBD and PD published from the beginning to October 2019

After excluding confounding factors and heterogeneity studies, the total risk of PD in patients with IBD was significantly higher than that of the general population (adjusted hazard ratio [RR]=1.

Patients over 65 years of age with inflammatory bowel disease are associated with the development of Parkinson's disease

Patients over 65 years of age with inflammatory bowel disease are associated with the development of Parkinson's disease

Patients under 65 years of age with inflammatory bowel disease are associated with the development of Parkinson's disease

Patients under 65 years of age with inflammatory bowel disease are associated with the development of Parkinson's disease

However, older patients (>65 years old) with IBD (adjusted HR=1.

The Meta analysis showed that there is a certain correlation between IBD IBD and PD, suggesting that IBD may moderately increase the risk of PD, especially in patients over 65 years of age

Zhu Y, Yuan M, Liu Y, Yang F, Chen WZ, Xu ZZ, Xiang ZB, Xu RS.