Neural stem cells secrete PTN to promote the development of their children's newborn neurons.

In 1978, Schofield first proposed a definition of the microenvironment of stem cells, and found that local microenvironments were necessary for the maintenance of stem stem cell dryness.
since then, more and more studies have defined the stem cell microenvironment of various tissues.
However, whether stem cells themselves can be a micro-environmental factor and thus affect the development of their sub-cells has not been fully revealed.
in the microenvironment of adult nerve symnosis, adult nerve stem/precursor cells can produce functional neurons throughout their lives, participate in learning memory, etc.
the process of adult nerve seamount, newborn neurons are able to release feedback suppressive signals to regulate the proliferation and differentiation of neural stem cells and fate.
However, it is not clear whether neural stem cells can regulate the development of newborn neurons.
Guo Weixiang of the Institute of Genetics and Developmental Biology of the Chinese Academy of Sciences, through cell removal, retrovirus-mediated single-cell markers, and signalpath regulation, found that neural stem cells can continue to provide Pleiotrophin (PTN) ligandtos to promote the development of their children's newborn neurons.
without prior feeding, new neuronal dendritics develop abnormally. further studies
found that PTN promotes the development of the new neurons of the hippocampus by acting primarily on ALK receptors on newborn neurons, thereby activating the AKT signaling pathway.
as we age, the number of neural stem cells decreases, and new neurons exhibit developmental abnormalities.
more importantly, the study found that the level of expression of PTN and the activity of the AKT signaling pathway mediated by it both decreased with age.
However, providing PTN with foreign aid or activating AKT signals can improve the development altimelias of newborn neurons caused by aging.
the results suggest that the lack of neural stem cell-derived PTN factors may be one of the reasons why cognitive ability declines with aging in the microenvironment of adult nerves.
the results were published online November 27 in the journal Neuron, a neuroscience journal.
Guo Weixiang group doctoral student Tang Changyong as the first author of the paper, Guo Weixiang as the communication author.
the study was helped by Wu Qingfeng, a researcher at the Institute of Genetic Development, on bioinformatics analysis and experimental design, Cui Yaxiong of the Academy of Military Medical Sciences has given great help in the staining of brain tissue slicing.
the research was funded by the Chinese Academy of Sciences, the National Natural Science Foundation of China and the Central Group's Youth Thousand Program.
Source: Institute of Genetics and Developmental Biology.