Neurology: Amyloid and cerebrovascular disease loads affect changes in brain function networks to varying degrees

Objective The purpose of this study is to assess the effect of mild cognitive impairment (MCI) baseline Alzheimer's disease (AD) and cerebral vascular disease load indicators on changes in functional connectivity (FC) of vertical default networks (DMNs) and advanced control networks (ECN)Methods This study included obstrual MCI (aMCI) patients and 55 patients with hypothalic hypothalamus MCI (svMCI), parallel Pittsburgh Mixture B (PiB) PET scan and longitudinal MRI scanThe subjects were followed for 4 years with MRI (once a year)Results The beta-amyloid (A-beta) load was correlated with the decline of longitudinal DMN FC, while the cerebrovascular disease load was correlated with the change of longitudinal ECN FCWhen patients were divided into PiB-plus and PiB-group, patients in the PiB-plus group experienced a decline in longitudinal DMN FC, while svMCI experienced an increase in longitudinal ECN FCIn cases without mixed pathology (aMCI PiB, svMCI PiB-), a direct comparison of 2 groups showed that aMCI PiB-plus patients had a steeper vertical DMN FC decline, while svMCI PiB-patients had steeper ECN FC elevationsFinally, using baseline PiB ingestion and cavity cerebral infarction as a continuous variable, the baseline PiB bureau showed that the vertical DMN FC change had an anti-U-type correlation in the two groups of MCI subtypes, while the number of baseline cavity cerebral infarctions showed that the vertical ECN FC change had an anti-U-type correlation in svMCI patientsConclusion The results of this study show different effects on vertical FC changes in DMN and ECN in patients with pre-dementia, indicating that potential pathological changes can be used as a method for evaluating early changes in AD and cerebrovascular disease