Neurology: Angiotensin II stimulates antihypertensive drugs, or helps prevent dementia

High blood pressure in middle-life is associated with an increased risk of dementia.
, studies of lower blood pressure in older adults have shown that reducing the risk of Alzheimer's disease has many effects.
growing evidence that some antihypertensive drug subcates may reduce dementia events more than their effects on BP.
other antihypertensive drugs, the subcatfacies most associated with reducing the risk of dementia are angiotensin blockers, certain calcium channel blockers, and diuretics.
As based on the "angiosin hypothesis", assess whether angiotrophosin II stimulating antihypertrophic drugs (calcium channel blockers and angiosin I blockers) have a lower risk of dementia than angiosin II inhibitors (angiosin i-convertase inhibitors, β-blockers and non-dihydrocarbons.
Willem van Dalen of the University of Amsterdam and others followed 1909 people (54% of women) in a dementia-free community aged 70 to 78 using Cox regression analysis.
the effects of class II angiosin stimulation and inhibitory anti-depressive anti-depressants on the risk of dementia.
results showed that after an average follow-up of 6.7 years, angiosin II stimulation: 5.6% (27/480) was associated with dementia;
After adjusting for risk factors for dementia such as blood pressure and medical history, the risk of dementia decreased by 45% and the risk of dementia by 20% compared to users of angiotensin II-inhibiting antihypotensive drugs.
the main significance of this study is that compared with angiotensin II inhibitor antihypertensive drugs, angiotensin II stimulating antihypertensive drug users have a lower incidence of dementia, supporting the angiotensin hypothesis.
if this study can be repeated by other similar studies, for older people receiving antihypertensive treatment, the use of angiotensin II stimulating antihypertensive drugs may help prevent dementia.