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A milestone in Alzheimer's disease (AD) clinical trials is the addition of PET imaging and CSF biomarkers to exclude AD analogs and even design secondary prevention trials for subjects with preclinical AD1 .
prevention
However, the success of a trial still depends on the change in the rate of cognitive decline between the test treatment and the placebo, which is hindered by the huge difference in the rate of clinical progress between participants.
diagnosis
Therefore, it can be speculated that APOE alleles have different effects on cognition.
Therefore, it can be speculated that APOE alleles have different effects on cognition.
The results showed that the increase rate of CDR-SOB in APOEε4 carriers was ≈1.
The MMSE decline rate of APOEε4 carriers was ≈1.
The MMSE decline rate of APOEε4 carriers was ≈1.
The important significance of this study is that it is found that compared with the reference genotype of APOEε3/ε3, APOEε2 and ε4 alleles have opposite effects on the rate of cognitive decline (reduction and acceleration, respectively), which are clinically relevant and basically independent The different effects of APOE alleles on AD and combined pathology.
neurology.
org/content/early/2021/03/25/WNL.
0000000000011894" target="_blank" rel="noopener">Association of Gyrification Pattern, White Matter Changes , and Phenotypic Profile in Patients With Parkinson DiseaseXie Tang, Yuanchao Zhang, Daihong Liu, Yixin Hu, Lingli Jiang, Jiuquan ZhangNeurology Mar 2021, 10.
1212 / WNL.
0000000000011894; DOI: 10.
1212 / WNL.
0000000000011894
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