Neurology: Autopsy validation of the diagnostic accuracy of (123) I-m-iodophenylguanidine myocardial imaging for Lewy body disease

Lewy body disease is characterized by Lewy bodies composed of α-synuclein, and it encompasses a range of diagnoses , including Parkinson's disease (PD) and dementia with Lewy bodies (DLB)

Several studies have evaluated ⁽¹²³⁾ the diagnostic accuracy of I-MIBG myocardial imaging for LBDS

^{The diagnostic accuracy of (123)} I-MIBG myocardial scintigraphy in differentiating LBD from similar disorders has been determined based on large autopsy cases

This retrospective cross-sectional study included serial autopsy patients from the Aging Research Brain Bank who underwent 123I-MIBG cardionuclide scans

• The data of 56 patients were analyzed, of which 30 were pathologically confirmed LBDS, and 26 had no pathological changes of LBD
  
  This clinicopathological validation study demonstrated that ⁽¹²³⁾ I-MIBG myocardial imaging can effectively differentiate LBDS from similar disorders
  
  Source: Matsubara T, Kameyama M, Tanaka N, et al.
  Autopsy Validation of the Diagnostic Accuracy of 123I-Metaiodobenzylguanidine Myocardial Scintigraphy for Lewy Body Disease.
  Neurology.
  2022;98(16):e1648-e1659.
  doi:10.
  1212/WNL .
  0000000000200110 Matsubara T, Kameyama M, Tanaka N, et al.
  Autopsy Validation of the Diagnostic Accuracy of 123I-Metaiodobenzylguanidine Myocardial Scintigraphy for Lewy Body Disease.
  Neurology.
  2022;98(16):e1648-e1659.
  doi:10.
  1212/WNL.
  0000000000200110
  
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