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Charcot-Marie-Tooth disease (CMT) is the most common hereditary neuromuscular disease.
About 1 in 2500 people suffer from a wide range of phenotypic variants, including genetic diseases mainly related to peripheral nervous system motor and sensory defects
.
CMT is characterized by reduced muscle volume from distal to proximal end, muscle weakness, sensory loss, no reflex, hand-foot deformity, CMT classification is based on the type of nerve injury, hereditary pattern and potential genetic mutations
child
Gabrielle A.
Donlevy et al.
investigated the association between body mass index (BMI) and the disability of children with Charcot-Marie-Tooth disease (CMT)
.
Donlevy et al.
investigated the association between body mass index (BMI) and the disability of children with Charcot-Marie-Tooth disease (CMT)
.
The study conducted a cross-sectional analysis of 477 CMT patients between the ages of 3 and 20 and 316 healthy children who were age- and gender-matched
.
BMI is classified according to the International Obesity Task Force (IOTF) standards, and the BMI classification is compared with healthy children
2 2 2 2 2
Mean (standard error) of CMTPedS disability score according to BMI classification
Mean (standard error) of CMTPedS disability score according to BMI classificationCMTPedS project scores hand dexterity, muscle strength and strength scores classified by BMI
CMTPedS project scores hand dexterity, muscle strength and strength scores classified by BMIThe study found that children with CMT were classified as severely underweight (5.
7% vs.
0.
3%), underweight (10.
3% vs.
5.
1%), and obese (7.
3% vs.
3.
8%) at a higher rate (p <0.
05)
.
A small number of children with CMT were classified as healthy weight (61.
The CMTPedS item scores balance, endurance (6MWT), gait, and sensation (acupuncture, vibration) according to BMI categories
.
scores balance, endurance (6MWT), gait, and sensation (acupuncture, vibration) according to BMI categories .
The CMTPedS item scores balance, endurance (6MWT), gait, and sensation (acupuncture, vibration) according to BMI categories
Compared with healthy-weight children with CMT, severe underweight is associated with a higher degree of disability (p <0.
Compared with age- and gender-matched healthy children, children with CMT have a higher rate of underweight or obesity
Association Between Body Mass Index and Disability in Children With Charcot-Marie-Tooth Disease.
Association Between Body Mass Index and Disability in Children With Charcot-Marie-Tooth Disease.
Neurology Oct 2021, 97 (17) e1727-e1736; DOI: 10.
1212/WNL.
0000000000012725 Association Between Body Mass Index and Disability in Children With Charcot-Marie- .
Tooth Disease Neurology Oct 2021, 97 (17) e1727-e1736; DOI: 10.
1212 / WNL.
0000000000012725 in this message