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    Home > Active Ingredient News > Study of Nervous System > Neurology: Cardiovascular Risk Study in Finnish Youth: Persistently high levels of serum creatinine may be associated with better learning and memory function in middle-aged men!

    Neurology: Cardiovascular Risk Study in Finnish Youth: Persistently high levels of serum creatinine may be associated with better learning and memory function in middle-aged men!

    • Last Update: 2022-05-23
    • Source: Internet
    • Author: User
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    As the prevalence of dementia increases, effective means of enhancing cognitive health before cognitive deficits appear are critical
    .
    It is well known that the pathophysiological processes leading to cognitive deficits begin years or decades before clinical symptoms appear

    .
    At the same time, there is currently no cure and few drug treatments to slow the progression of the disease after symptoms appear

    .
    Therefore, identifying early determinants of cognitive performance may play a critical role in both identifying at-risk individuals and reducing the burden of cognitive deficits

    .

    As the prevalence of dementia increases, effective means of enhancing cognitive health before cognitive deficits appear are critical
    .
    It is well known that the pathophysiological processes leading to cognitive deficits begin years or decades before clinical symptoms appear

    .
    At the same time, there is currently no cure and few drug treatments to slow the progression of the disease after symptoms appear

    .
    Therefore, identifying early determinants of cognitive performance may play a critical role in both identifying at-risk individuals and reducing the burden of cognitive deficits

    .

    Serum creatinine is an indicator of renal function and can be used to calculate estimated glomerular filtration rate (EGFR)
    .
    Previous studies have demonstrated low EGFR due to elevated serum creatinine, suggesting that impaired renal function is associated with lower cognitive performance and higher all-cause mortality

    .
    However, non-linear correlations of EGFR have also been reported, as high EGFR (ie, low serum creatinine) is associated with an increased risk of all-cause and cardiovascular mortality

    .
    In addition, several studies have shown that high EGFR in middle and old age is associated with cognitive decline and increased incidence of dementia

    .

    Serum creatinine is an indicator of renal function and can be used to calculate estimated glomerular filtration rate (EGFR)
    .
    Previous studies have demonstrated low EGFR due to elevated serum creatinine, suggesting that impaired renal function is associated with lower cognitive performance and higher all-cause mortality

    .
    However, non-linear correlations of EGFR have also been reported, as high EGFR (ie, low serum creatinine) is associated with an increased risk of all-cause and cardiovascular mortality

    .
    In addition, several studies have shown that high EGFR in middle and old age is associated with cognitive decline and increased incidence of dementia

    .

    The mechanism underlying the link between low serum creatinine and cognitive impairment is unclear
    .
    Low muscle mass or poor dietary habits may be the cause of low serum creatinine, two factors that have also been shown to be associated with poor cognitive performance

    .
    Low serum creatinine may indicate glomerular hyperfiltration, which occurs physiologically after pregnancy and a high-protein diet

    .
    Furthermore, as an adaptive response to nephron loss, increased filtration can lead to glomerular hypertension, which in turn leads to glomerulosclerosis, leading to progressive decline in renal function and glomerular damage

    .
    Importantly, glomerular hyperfiltration is considered an early manifestation of risk factors, such as diabetes, prediabetes, elevated blood pressure, obesity, and smoking, and is associated with cardiovascular endpoints (ie, death, congestive heart failure hospitalization, myocardial infarction, stroke)

    .
    In addition, glomerular hyperfiltration is thought to be associated with poor cognitive performance

    .
    However, systematic evidence on the relationship between midlife longitudinal serum creatinine levels and cognitive performance has previously been lacking

    .

    The mechanism underlying the link between low serum creatinine and cognitive impairment is unclear
    .
    Low muscle mass or poor dietary habits may be the cause of low serum creatinine, two factors that have also been shown to be associated with poor cognitive performance

    .
    Low serum creatinine may indicate glomerular hyperfiltration, which occurs physiologically after pregnancy and a high-protein diet

    .
    Furthermore, as an adaptive response to nephron loss, increased filtration can lead to glomerular hypertension, which in turn leads to glomerulosclerosis, leading to progressive decline in renal function and glomerular damage

    .
    Importantly, glomerular hyperfiltration is considered an early manifestation of risk factors, such as diabetes, prediabetes, elevated blood pressure, obesity, and smoking, and is associated with cardiovascular endpoints (ie, death, congestive heart failure hospitalization, myocardial infarction, stroke)

    .
    In addition, glomerular hyperfiltration is thought to be associated with poor cognitive performance

    .
    However, systematic evidence on the relationship between midlife longitudinal serum creatinine levels and cognitive performance has previously been lacking

    .

    Using data from the Young Finns Cardiovascular Risk Study (YFS), researchers sought to investigate the longitudinal association between serum creatinine and cognitive performance in middle age
    .
    The study hypothesized that, in participants without kidney disease, low serum creatinine during adulthood and midlife was a sign of poor cardiovascular health and was associated with poorer cognitive performance in midlife

    .

    Using data from the Young Finns Cardiovascular Risk Study (YFS), researchers sought to investigate the longitudinal association between serum creatinine and cognitive performance in middle age
    .
    The study hypothesized that, in participants without kidney disease, low serum creatinine during adulthood and midlife was a sign of poor cardiovascular health and was associated with poorer cognitive performance in midlife

    .

    Participants in the Finnish Youth Cardiovascular Risk Study have been followed for up to 10 years since 2001
    .
    Serum creatinine was repeated in 2001, 2007, and 2011

    .
    Sex-specific longitudinal trajectories of serum creatinine in participants without kidney disease were determined using a latency-growth mixed model

    .
    Global cognitive function and four specific domains such as 1) working memory, 2) episodic memory and associative learning, 3) reaction time, and 4) information processing were assessed by computerized cognitive tests

    .

    Participants in the Finnish Youth Cardiovascular Risk Study have been followed for up to 10 years since 2001
    .
    Serum creatinine was repeated in 2001, 2007, and 2011

    .
    Sex-specific longitudinal trajectories of serum creatinine in participants without kidney disease were determined using a latency-growth mixed model

    .
    Global cognitive function and four specific domains such as 1) working memory, 2) episodic memory and associative learning, 3) reaction time, and 4) information processing were assessed by computerized cognitive tests

    .

    • In men (N=973) and women (N=1,204), 4 serum creatinine trajectory groups were identified, all with clinically normal serum creatinine
      .
      After 10 years of follow-up, cognitive tests were administered to 2,026 participants aged 34 to 49 years (mean 41.
      8 years)

      .
    • In both men and women, persistent low serum creatinine was associated with poor childhood academic performance, low adult education, low annual income in adulthood, less physical activity, and smoking
      .
    • Overall cognitive performance (β=0.
      353 SD, 95%CI 0.
      022-0.
      684) and working memory (β=0.
      351 SD, 95%CI 0.
      034-0.
      668) were better in the high-creatinine group compared with the low-creatinine trajectory group, The episodic memory and associative learning abilities were better in the intermediate serum creatinine group (β=0.
      247 SD, 95%CI 0.
      026-0.
      468) or the normal serum creatinine group (β=0.
      244 SD, 95%CI 0.
      008-0.
      481)

      .
    • No link with women was found
      .
  • In men (N=973) and women (N=1,204), 4 serum creatinine trajectory groups were identified, all with clinically normal serum creatinine
    .
    After 10 years of follow-up, cognitive tests were administered to 2,026 participants aged 34 to 49 years (mean 41.
    8 years)

    .
  • In men (N=973) and women (N=1,204), 4 serum creatinine trajectory groups were identified, all with clinically normal serum creatinine
    .
    After 10 years of follow-up, cognitive tests were administered to 2,026 participants aged 34 to 49 years (mean 41.
    8 years)

    .
  • In both men and women, persistent low serum creatinine was associated with poor childhood academic performance, low adult education, low annual income in adulthood, less physical activity, and smoking
    .
  • In both men and women, persistent low serum creatinine was associated with poor childhood academic performance, low adult education, low annual income in adulthood, less physical activity, and smoking
    .
  • Overall cognitive performance (β=0.
    353 SD, 95%CI 0.
    022-0.
    684) and working memory (β=0.
    351 SD, 95%CI 0.
    034-0.
    668) were better in the high-creatinine group compared with the low-creatinine trajectory group, The episodic memory and associative learning abilities were better in the intermediate serum creatinine group (β=0.
    247 SD, 95%CI 0.
    026-0.
    468) or the normal serum creatinine group (β=0.
    244 SD, 95%CI 0.
    008-0.
    481)

    .
  • Overall cognitive performance (β=0.
    353 SD, 95%CI 0.
    022-0.
    684) and working memory (β=0.
    351 SD, 95%CI 0.
    034-0.
    668) were better in the high-creatinine group compared with the low-creatinine trajectory group, The episodic memory and associative learning abilities were better in the intermediate serum creatinine group (β=0.
    247 SD, 95%CI 0.
    026-0.
    468) or the normal serum creatinine group (β=0.
    244 SD, 95%CI 0.
    008-0.
    481)

    .
  • No link with women was found
    .
  • No link with women was found
    .

    The findings suggest that, in men, persistently high levels of serum creatinine may be associated with better memory and learning function in midlife compared with low levels of serum creatinine
    .

    The findings suggest that, in men, persistently high levels of serum creatinine may be associated with better memory and learning function in midlife compared with low levels of serum creatinine
    .

    Source: Hakala JO, Pahkala K, Juonala M, et al.
    Repeatedly Measured Serum Creatinine and Cognitive Performance in Midlife: The Cardiovascular Risk in Young Finns Study [published online ahead of print, 2022 Apr 11].
    Neurology.
    2022;10.
    1212/ WNL.
    0000000000200268.
    doi:10.
    1212/WNL.
    0000000000200268

    Source: Hakala JO, Pahkala K, Juonala M, et al.
    Repeatedly Measured Serum Creatinine and Cognitive Performance in Midlife: The Cardiovascular Risk in Young Finns Study [published online ahead of print, 2022 Apr 11].
    Neurology.
    2022;10.
    1212/ WNL.
    0000000000200268.
    doi:10.
    1212/WNL.
    0000000000200268
    Hakala JO, Pahkala K, Juonala M, et al.
    Repeatedly Measured Serum Creatinine and Cognitive Performance in Midlife: The Cardiovascular Risk in Young Finns Study [published online ahead of print, 2022 Apr 11 ].
    Neurology.
    2022; 10.
    1212/WNL.
    0000000000200268.
    doi: 10.
    1212/WNL.
    0000000000200268


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