Neurology: Chinese original research-Parkinson's motor phenotype is closely related to cortical folds

Parkinson's disease (PD) is a progressive neurodegenerative disease in the elderly, manifested by typical motor symptoms, such as resting tremor, stiffness, and slow movement, as well as non-motor symptoms.

Neuroimaging studies have documented different patterns of brain changes in TD and AR subtypes.

It is currently believed that cortical wrinkling is driven by potential white matter (WM) tension .

They found that compared with HCs, AR subtype patients had anterior, posterior, inferior and superior parietal lobe, middle and superior frontal/temporal lobe, anterior and posterior cingulate, anterior orbital lobe, superior margin, precuneus The LGI of part of the visual cortex decreased, and the FA of the corticospinal tract, lower and upper longitudinal tract, lower anterior occipital tract, and anterior thalamus decreased.

The reduction in LGI and FA of the AR subtype is tightly coupled.

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