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Neurology: Combining neuroanatomical and functional neuroimaging, cerebellar transcranial magnetic stimulation, cerebellar dysfunction in patients with PRRT2-related paroxysmal dyskinesia

 Last Update: 2022-03-02
 Source: Internet
 Author: User

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Paroxysmal movement-induced dyskinesia (PKD) is a brief, recurrent episode of dystonia or other involuntary movements, usually caused by sudden voluntary movements

In 22 patients with PRRT2-related PKD and 22 healthy controls, researchers combined a comprehensive anatomical and functional neuroimaging approach and transcranial magnetic stimulation of the cerebellum to study the role of cerebellar dysfunction in the pathogenesis of PRRT2-related PKD.

Decreased gray matter volume in cerebellar vi lobe and medial prefrontal cortex;
Microstructural changes in cerebellar tracts and cerebellar white matter connecting the cerebellum, striatum, and cortical motor areas;
Dysfunction of cerebellar motor pathways connecting striatal and cortical motor areas, and abnormal communication between the cerebellum associative prefrontal cortex and medial motor areas

Altered motor cerebellar convergent structures and related pathways in patients with PRRT2-related dyskinesia, dysfunction of cerebellar output leading to the cerebellar-thalamo-striatal-cortical network

Ekmen, Asya et al.

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