 Home > Active Ingredient News > Study of Nervous System > Neurology: Diffusion tensor imaging along perivascular spaces (DTI-ALPS) reveals associations between lymphatic function and neuropsychology, gray matter volume, sleep: Sleep health has implications for brain health

Neurology: Diffusion tensor imaging along perivascular spaces (DTI-ALPS) reveals associations between lymphatic function and neuropsychology, gray matter volume, sleep: Sleep health has implications for brain health

 Last Update: 2022-01-23
 Source: Internet
 Author: User

Tags

non digital scale

sleep medication hydroxyzine

Search more information of high quality chemicals, good prices and reliable suppliers, visit www.echemi.com

The discovery of the lymphatic system provides a new perspective for studying brain protein homeostasis and a promising target for the prevention and treatmentof neurodegenerative diseases
.
This highly organized fluid transport system includes the inflow of cerebrospinal fluid (CSF) along the perivascular space (PVS) and facilitated transfer to the brain interstitium by the water channel 4 (AQP4) water channel

Prevention of cerebrospinal fluid (CSF) perivascular space (PVS) vessels

Experiments in rodents have provided considerable insight into lymphatic physiology, particularly with regard to the relationship between sleep and the lymphatic system
.
Growing evidence suggests that non-rapid eye movement (NREM) sleep potently promotes lymphatic fluid transport, whereas it is inhibited during wakefulness

Although a great deal of knowledge has been gained from animal studies, further research is necessary to confirm whether findings about the animal's lymphatic system are applicable to humans
.
Small-scale studies in humans echo findings in rodents to some extent, but the invasiveness of current assessment tools, such as intrathecal injection of contrast agents, limits comprehensive studies of the lymphatic system in humans

Taoka et al.

DTI-Alps presents an opportunity for non-invasive studies of the human lymphatic system, using this method to assess the lymphatic system in a community-based non-demented elderly population with the aim of correlating lymphatic function with sleep, neuropsychological performance, and gray matter volume connection between

This cross-sectional study included individuals 60 years of age or older who participated in a study integrating geriatric system data to explore solutions for healthy aging between September 2019 and October 2020

Participants with dementia, major depressive disorder and other major organ system abnormalities were excluded

A total of 84 participants (mean age 73.

3 [7.

The study identified a significant association between lymphatic function and sleep, underscoring the importance of sleep for brain health

Siow TY, Toh CH, Hsu JL, Liu GH, Lee SH, Chen NH, Fu CJ, Castillo M, Fang JT.
Association of Sleep, Neuropsychological Performance, and Gray Matter Volume With Glymphatic Function in Community-Dwelling Older Adults.
Neurology.
2021 Dec 14:10.
1212/WNL.
0000000000013215.
doi: 10.
1212/WNL.
0000000000013215.
Epub ahead of print.
PMID: 34906982.
Leave a message here

This article is an English version of an article which is originally in the Chinese language on echemi.com and is provided for information purposes only. This website makes no representation or warranty of any kind, either expressed or implied, as to the accuracy, completeness ownership or reliability of the article or any translations thereof. If you have any concerns or complaints relating to the article, please send an email, providing a detailed description of the concern or complaint, to service@echemi.com. A staff member will contact you within 5 working days. Once verified, infringing content will be removed immediately.